Evidence map›Paper›PMID 34387110›Full record

Observational studyJournal of the American Heart Association2021

Association of Mildly Reduced Kidney Function With Cardiovascular Disease: The Framingham Heart Study.

Feven Ataklte, Rebecca J Song, Ashish Upadhyay, Ibrahim Musa Yola, Ramachandran S Vasan, Vanessa Xanthakis

Open access · goldAbstract readComparative StudyObservational Study
In one paragraph

Observational study in Journal of the American Heart Association, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Association between hemoglobin-to-creatinine ratio and all-cause mortality in patients with coronary artery disease.The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology · 2025
    Article
  5. Review
  6. Article
  7. Sex-specific effects of mild kidney dysfunction on vascular function in midlife and older adults.American journal of physiology. Heart and circulatory physiology · 2025
    Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Feven AtaklteDepartment of Internal Medicine Boston Medical Center and Boston University School of Medicine Boston MA.
Rebecca J SongDepartment of Epidemiology Boston University School of Public Health Boston MA.
Ashish UpadhyaySection of Nephrology Boston Medical Center and Boston University School of Medicine Boston MA.
Ibrahim Musa YolaSection of Preventive Medicine and Epidemiology Department of Medicine Boston University School of Medicine Boston MA.
Ramachandran S VasanDepartment of Epidemiology Boston University School of Public Health Boston MA.
Vanessa XanthakisDepartment of Biostatistics Boston University School of Public Health Boston MA.
Boston University · US

Funding

FRAMINGHAM HEART STUDY - YEAR 5 EXAM75N92019D00031 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI RAMACHANDRAN, VASAN · 2019 to 2024
$29.8M
Multidisciplinary Training Program in Cardiovascular EpidemiologyT32HL125232 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI Matthew G. Nayor, Vanessa Xanthakis · 2016 to 2026
$5.0M
PRIMER: Promoting Research In MEdical ResidencyR38HL143584 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI Darrell N. Kotton, Matthew G. Nayor · 2020 to 2026
$2.1M
THE FRAMINGHAM HEART STUDY-N01HC25195-268025195-268025195N01HC025195 · HC · TRUSTEES OF BOSTON UNIVERSITY · PI WOLF, PHILIP A · 2002 to 2006
–
NHLBI NIH HHS 75N92019D00031NHLBI NIH HHS HHSN268201500001INHLBI NIH HHS N01 HC025195NHLBI NIH HHS R38 HL143584NHLBI NIH HHS T32 HL125232
6 · The paper itself

Abstract

Background Data are limited on the association of mildly reduced estimated glomerular filtration rate (eGFR 60-89 mL/min per 1.73 m

Indexed as

Glomerular Filtration RateAgedCardiovascular DiseasesCross-Sectional StudiesDisease ProgressionFemaleHeart Disease Risk FactorsHumansIncidenceKidneyKidney DiseasesMaleMassachusettsMiddle AgedPrevalencePrognosisbiomarkerscardiovascular diseaseglomerular filtration ratemild kidney diseasesubclinical disease

Identifiers

PMID34387110
PMCPMC8475034
OpenAlexW3190193257

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.