Evidence map›Paper›PMID 34387095›Full record

ArticleCirculation. Cardiovascular imaging2021

Progress and Research Priorities in Imaging Genomics for Heart and Lung Disease: Summary of an NHLBI Workshop.

Matthew Nayor, Li Shen, Gary M Hunninghake, Peter Kochunov, R Graham Barr, David A Bluemke, Ulrich Broeckel, Peter Caravan, Susan Cheng, Paul S de Vries and 8 more

Abstract readConference Proceedings
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation. Cardiovascular imaging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Matthew NayorSections of Cardiology and Preventive Medicine and Epidemiology, Department of Medicine, Boston University School of Medicine, MA (M.N.).
Li ShenDepartment of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia (L.S.).
Gary M HunninghakeDivision of Pulmonary and Critical Care Medicine, Harvard Medical School, Brigham and Women's Hospital, Boston, MA (G.M.H.).
Peter KochunovMaryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore (P.K.).
R Graham BarrDepartment of Medicine and Department of Epidemiology, Mailman School of Public Health, Columbia University Irving Medical Center, New York (R.G.B.).
David A BluemkeDepartment of Radiology, University of Wisconsin-Madison School of Medicine and Public Health (D.A.B.).
Ulrich BroeckelSection of Genomic Pediatrics, Department of Pediatrics, Medicine and Physiology, Children's Research Institute and Genomic Sciences and Precision Medicine Center, Medical College of Wisconsin, Milwaukee (U.B.).
Peter CaravanInstitute for Innovation in Imaging, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown (P.C.).
Susan Cheng
Paul S de VriesDepartment of Cardiology, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA. Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston (P.S.d.V.).
Udo HoffmannDepartment of Radiology, Harvard Medical School, Massachusetts General Hospital, Boston (U.H., M.K.).
Márton KolossváryDepartment of Radiology, Harvard Medical School, Massachusetts General Hospital, Boston (U.H., M.K.).
Huiqing LiDivision of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, Bethesda, MD (H.L., J.L.).
James LuoDivision of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, Bethesda, MD (H.L., J.L.).
Elizabeth M McNallyCenter for Genetic Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL (E.M.M.).
George ThanassoulisPreventive and Genomic Cardiology, McGill University Health Center and Research Institute, Montreal, Quebec, Canada (G.T.).
Donna K Arnett *College of Public Health, University of Kentucky, Lexington (D.K.A.).
Ramachandran S Vasan *Sections of Preventive Medicine and Epidemiology, and Cardiology, Department of Medicine, Department of Epidemiology, Boston University Schools of Medicine and Public Health, and Center for Computing and Data Sciences, Boston University, MA (R.S.V.).

Funding

Clinical and Translational Science AwardUL1TR001873 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI REILLY, MUREDACH P · 2016 to 2025
$99.0M
Northwestern University Clinical and Translational Science Institute (NUCATS)UL1TR001422 · NCATS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI D'AQUILA, RICHARD · 2015 to 2023
$56.8M
RURAL: Risk Underlying Rural Areas Longitudinal Cohort StudyU01HL146382 · NHLBI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI JUDD, SUZANNE E, RAMACHANDRAN, VASAN · 2019 to 2025
$42.5M
FRAMINGHAM HEART STUDY - YEAR 5 EXAM75N92019D00031 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · 2019 to 2024
$29.8M
The Effects of Kynurenine Aminotransferase Inhibition in People with SchizophreniaP50MH103222 · NIMH · UNIVERSITY OF MARYLAND BALTIMORE · PI SCHWARCZ, ROBERT · 2014 to 2023
$25.2M
Ultrascale Machine Learning to Empower Discovery in Alzheimers Disease BiobanksU01AG068057 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Christos Davatzikos, Heng Huang · 2020 to 2026
$20.7M
Pulmonary microvascular perfusion in the Multi-Ethnic Study of AtherosclerosisR01HL077612 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI R Graham BARR · 2004 to 2026
$18.8M
HYPERGEN: GENETICS OF LEFT VENTRICULAR HYPERTROPHYR01HL055673 · NHLBI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI ARNETT, DONNA K · 1996 to 2016
$18.1M
Research BaseP30DK072488 · NIDDK · UNIVERSITY OF MARYLAND BALTIMORE · PI MITCHELL, BRAXTON D · 2005 to 2019
$17.3M
Pulmonary Vascular Changes in Early Chronic Obstructive Pulmonary Disease (COPD)R01HL093081 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI R Graham BARR · 2008 to 2026
$17.2M
Clinical Genetics and Screening for Pulmonary FibrosisR01HL130974 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI GARY MATTHEW HUNNINGHAKE, Benjamin Alexander Raby · 2016 to 2026
$10.0M
PET Imaging of ThrombusR01HL109448 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI CARAVAN, PETER D, SOSNOVIK, DAVID E · 2011 to 2025
$9.6M
NCATS NIH HHS UL1 TR001422NCATS NIH HHS UL1 TR001873NHGRI NIH HHS U01 HG011169NHLBI NIH HHS 75N92019D00031NHLBI NIH HHS HHSN268201500001CNHLBI NIH HHS HHSN268201500001INHLBI NIH HHS K23 HL138260NHLBI NIH HHS N01 HC025195NHLBI NIH HHS R01 HL055673NHLBI NIH HHS R01 HL077612NHLBI NIH HHS R01 HL093081NHLBI NIH HHS R01 HL093328NHLBI NIH HHS R01 HL107385NHLBI NIH HHS R01 HL107577NHLBI NIH HHS R01 HL109448NHLBI NIH HHS R01 HL111024NHLBI NIH HHS R01 HL116315NHLBI NIH HHS R01 HL121270NHLBI NIH HHS R01 HL125580NHLBI NIH HHS R01 HL126136NHLBI NIH HHS R01 HL128075NHLBI NIH HHS R01 HL128550NHLBI NIH HHS R01 HL130974NHLBI NIH HHS R01 HL131532NHLBI NIH HHS R01 HL131907NHLBI NIH HHS R01 HL134168NHLBI NIH HHS R01 HL135142NHLBI NIH HHS R01 HL140493NHLBI NIH HHS R01 HL142028NHLBI NIH HHS R01 HL142983NHLBI NIH HHS R01 HL143227NHLBI NIH HHS R01 HL146860NHLBI NIH HHS R33 HL154125NHLBI NIH HHS U01 HL131914NHLBI NIH HHS U01 HL146382NIA NIH HHS U01 AG068057NIBIB NIH HHS R01 EB015611NIBIB NIH HHS R01 EB022574NIDDK NIH HHS P30 DK072488NIDDK NIH HHS P30 DK114857NIMH NIH HHS P50 MH103222NIMH NIH HHS R01 MH116948NIMH NIH HHS R01 MH133812NIMH NIH HHS U01 MH108148NINDS NIH HHS R01 NS114628NINDS NIH HHS RF1 NS114628NLM NIH HHS R01 LM013463
6 · The paper itself

Abstract

Imaging genomics is a rapidly evolving field that combines state-of-the-art bioimaging with genomic information to resolve phenotypic heterogeneity associated with genomic variation, improve risk prediction, discover prevention approaches, and enable precision diagnosis and treatment. Contemporary bioimaging methods provide exceptional resolution generating discrete and quantitative high-dimensional phenotypes for genomics investigation. Despite substantial progress in combining high-dimensional bioimaging and genomic data, methods for imaging genomics are evolving. Recognizing the potential impact of imaging genomics on the study of heart and lung disease, the National Heart, Lung, and Blood Institute convened a workshop to review cutting-edge approaches and methodologies in imaging genomics studies, and to establish research priorities for future investigation. This report summarizes the presentations and discussions at the workshop. In particular, we highlight the need for increased availability of imaging genomics data in diverse populations, dedicated focus on less common conditions, and centralization of efforts around specific disease areas.

Indexed as

Biomedical ResearchImaging GenomicsAnimalsArtificial IntelligenceDiffusion of InnovationGenetic Predisposition to DiseaseGenetic VariationHeart DiseasesHumansLung DiseasesNational Heart, Lung, and Blood Institute (U.S.)PhenotypePredictive Value of TestsPrognosisUnited Statescardiovascular diseasegenomicsphenotypepreventionproteins

Identifiers

PMID34387095
PMCPMC8486340

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.