Evidence map›Paper›PMID 34387046›Full record

ArticleJournal of periodontal & implant science2021

The effects of zoledronic acid on the progression of experimental periodontitis in rats: histological and microtomographic analyses.

Priscylla Gonçalves Correia Leite de Marcelos, Danyel Elias Da Cruz Perez Perez, Diego Moura Soares, Samuel Silva de Araújo, Liriane Baratella Evêncio, Maria Luiza Dos Anjos Pontual, Flávia Maria De Moraes Ramos-Perez

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of periodontal & implant science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Priscylla Gonçalves Correia Leite de MarcelosUniversidade Federal de Alagoas School of Dentistry, Maceió, AL, Brazil.ORCID https://orcid.org/0000-0002-5623-6835
Danyel Elias Da Cruz Perez PerezDepartment of Clinical and Preventive Dentistry, Oral Pathology and Oral Radiology Sections, Universidade Federal de Pernambuco School of Dentistry, Recife, PE, Brazil. danyel.perez@ufpe.br.ORCID https://orcid.org/0000-0002-4591-4645
Diego Moura SoaresDepartment of Clinical and Preventive Dentistry, Oral Pathology and Oral Radiology Sections, Universidade Federal de Pernambuco School of Dentistry, Recife, PE, Brazil.ORCID https://orcid.org/0000-0002-9842-6709
Samuel Silva de AraújoDepartment of Clinical and Preventive Dentistry, Oral Pathology and Oral Radiology Sections, Universidade Federal de Pernambuco School of Dentistry, Recife, PE, Brazil.ORCID https://orcid.org/0000-0002-8240-0029
Liriane Baratella EvêncioDepartment of Histology, Universidade Federal de Pernambuco, Recife, PE, Brazil.ORCID https://orcid.org/0000-0003-0560-0681
Maria Luiza Dos Anjos PontualDepartment of Clinical and Preventive Dentistry, Oral Pathology and Oral Radiology Sections, Universidade Federal de Pernambuco School of Dentistry, Recife, PE, Brazil.ORCID https://orcid.org/0000-0002-5900-8328
Flávia Maria De Moraes Ramos-PerezDepartment of Clinical and Preventive Dentistry, Oral Pathology and Oral Radiology Sections, Universidade Federal de Pernambuco School of Dentistry, Recife, PE, Brazil.ORCID https://orcid.org/0000-0001-9948-0769
Universidade Federal de Pernambuco · BRUniversidade Federal de Alagoas · BR

Funding

Conselho Nacional de Desenvolvimento Científico e TecnológicoCoordenação de Aperfeiçoamento de Pessoal de Nível Superior 001
6 · The paper itself

Abstract

purposePeriodontitis is considered a local risk factor for medication-related osteonecrosis of the jaws (MRONJ). However, little is known about the progression of periodontitis in the presence of zoledronic acid (ZOL). The aim of this study was to evaluate the effects of the systemic use of ZOL on the progression of experimental periodontitis (EP) in rats, as ZOL could modulate the progression of periodontitis and concomitantly cause MRONJ in individuals with periodontitis.

methodsForty-eight male Wistar rats were randomly distributed in 6 groups (n=8 each). To induce EP, ligatures were placed around the right first mandibular molars. Three groups were treated with ZOL (0.15 mg/kg/week, intraperitoneal), and 3 with 0.9% saline solution (controls). In the ZOL/Lig30 and ZOL/Lig 15 groups, after 4 weeks of treatment with ZOL, EP was induced and euthanasia was performed after 30 and 15 days of EP induction, respectively. In both groups, the animals continued to receive ZOL after EP until the end of the experiment. In the Lig/ZOL group, EP was induced first, and 15 days later, ZOL was administered for 8 weeks, with euthanasia 1 week after the last dose. After euthanasia, the mandibles were evaluated using micro-computed microtomography (micro-CT) and histomorphometry. Bone loss was measured, and the presence of osteonecrosis was evaluated histologically. The data were evaluated using the Student t-test and the Mann-Whitney test, with a significance level of 5%.

resultsIn the Lig/ZOL group, micro-CT revealed less alveolar bone resorption in the distal root (

conclusionZOL decreased alveolar bone resorption in rats with EP. However, it presented a higher risk for MRONJ.

Indexed as

HistologyOsteonecrosisPeriodontitisRatsX-ray microtomographyZoledronic acid

Identifiers

PMID34387046
PMCPMC8367644
OpenAlexW3161990571

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.