ArticleAnnals of surgical oncology2022
Thyroglobulin Measurement Through Fine-Needle Aspiration for Optimizing Neck Node Dissection in Papillary Thyroid Cancer.
Article in Annals of surgical oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 19 citations in OpenAlex.
- Article
- Prognostic value of FNA-Tg for local recurrence following lateral neck dissection in papillary thyroid carcinoma.BMC endocrine disorders · 2026Article
- Antibody-Stratified FNA-Thyroglobulin Cut-Off Values for Preoperative Lymph Node Assessment in Differentiated Thyroid Cancer.Diagnostics (Basel, Switzerland) · 2026Article
- Preoperative diagnosis of lateral cervical lymph node metastasis in papillary thyroid carcinoma: a multimodal ultrasound model integrating super-resolution ultrasound.Cancer imaging : the official publication of the International Cancer Imaging Society · 2026Article
- Evaluation of relevant indicators in the diagnosis of cervical lymph node metastasis in papillary thyroid cancer.Frontiers in oncology · 2026Article
- FNA-Tg improves the diagnostic efficacy of FNAC for PTC lateral cervical LN metastasis.Scientific reports · 2025Article
- How Many Lymph Nodes are Enough in Thyroidectomy? A Cohort Study Based on Real-World Data.Annals of surgical oncology · 2025Article
- Article
- Detection of thyroglobulin for diagnosis of metastatic lateral cervical lymph nodes in papillary thyroid carcinoma: accuracy and application in clinical practice.Translational cancer research · 2024Article
- The diagnosis and management of small and indeterminate lymph nodes in papillary thyroid cancer: preoperatively and intraoperatively.Frontiers in endocrinology · 2024Review
- Ultrasound-guided fine needle aspiration thyroglobulin in the diagnosis of lymph node metastasis of differentiated papillary thyroid carcinoma and its influencing factors.Frontiers in endocrinology · 2024Article
- Article
- Constructing a nomogram based on the distribution of thyroid nodules and suspicious lateral cervical lymph nodes in fine-needle aspiration biopsies to predict metastasis in papillary thyroid carcinoma.Frontiers in endocrinology · 2023Article
- The influence of thyroid status, serum Tg, TSH, and TgAb on FNA-Tg in cervical metastatic lymph nodes of papillary thyroid carcinoma.Laryngoscope investigative otolaryngology · 2022Article
- ASO Author Reflection: Optimizing Lateral Neck Dissection Extent of PTC by FNA-Tg.Annals of surgical oncology · 2022Article
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9 authors at 1 institution in 1 country.
Funding
Abstract
backgroundThyroglobulin measurement in fine-needle aspiration (FNA-Tg) is an additional diagnostic tool of lymph node metastasis (LNM) in papillary thyroid carcinoma (PTC). However, its performance as a preoperative indicator of lateral neck LNM in PTC is unclear. We evaluated the use of FNA cytology and FNA-Tg to detect neck LNM presurgery using a simple methodology, and established a cut-off value for diagnosing LNM in PTC.
methodsWe performed a retrospective cohort study based on hospital records, including 299 FNA-Tg measurements from 228 patients with PTC. The cut-off value for FNA-Tg was obtained through a receiver operating characteristic (ROC) curve analysis. The relationships between various parameters and FNA-Tg were analyzed using Spearman's correlation.
resultsOf 299 lymph nodes (LNs) from 228 patients following surgery, 151 were malignant and 148 were benign. The median FNA-Tg levels were 414.40 ng/mL and 6.36 ng/mL in the metastatic and benign LNs, respectively. An FNA-Tg cut-off value of 28.3 ng/mL had the best diagnostic performance (93.38% sensitivity, 70.27% specificity, area under the ROC curve [AUC] 0.868) in the whole cohort. The diagnostic value performed better in the lateral neck group (level II-V, n = 163) than in the central neck group (level VI, n = 136); in the lateral neck group, the sensitivity and specificity of the FNA-Tg cut-off (16.8 ng/mL) were 96.25% and 96.36%, respectively.
conclusionsFNA-Tg is a useful technique for the diagnosis of LNM before surgery, especially in lateral neck dissection. CLINICAL TRIAL REGISTRATION NUMBER: ChiCTR1900028547.
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