Evidence map›Paper›PMID 34386901›Full record

ArticleInternational journal of computer assisted radiology and surgery2021

Usefulness of X-ray dark-field imaging in the evaluation of local recurrence after nipple-sparing mastectomy.

Naoki Sunaguchi, Daisuke Shimao, Rieko Nishimura, Akari Iwakoshi, Tetsuya Yuasa, Masami Ando, Shu Ichihara

Abstract read
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In one paragraph

Article in International journal of computer assisted radiology and surgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 1 country.

Naoki SunaguchiDepartment of Radiological and Medical Laboratory Sciences, Nagoya University Graduate School of Medicine, Nagoya, Japan. sunaguchi@met.nagoya-u.ac.jp.ORCID http://orcid.org/0000-0002-2303-9763
Daisuke ShimaoDepartment of Radiological Technology, Hokkaido University of Science, Sapporo, Japan.
Rieko NishimuraDepartment of Pathology, Clinical Research Center, Nagoya Medical Center, Nagoya, Japan.
Akari IwakoshiDepartment of Pathology, Clinical Research Center, Nagoya Medical Center, Nagoya, Japan.
Tetsuya YuasaGraduate School of Engineering and Science, Yamagata University, Yonezawa, Japan.
Masami AndoHigh Energy Accelerator Research Organization, Tsukuba, Japan.
Shu IchiharaDepartment of Pathology, Clinical Research Center, Nagoya Medical Center, Nagoya, Japan.
Nagoya Medical Center · JPHigh Energy Accelerator Research Organization · JPHokkaido University of Science · JPNagoya City University · JPYamagata University · JP

Funding

japanese ministry of education, culture, sports, science and technology 21K04077Japanese Ministry of Education, Culture, Sports, Science and Technology 15H01129Japanese Ministry of Education, Culture, Sports, Science and Technology 16K01369Japanese Ministry of Education, Culture, Sports, Science and Technology 18K13765Japanese Ministry of Education, Culture, Sports, Science and Technology 26286079
6 · The paper itself

Abstract

purposeOur previous study suggests that the cross-sectional morphology of ducts and branching of ducts in the nipple are associated with the presence of breast cancer. In this study, we evaluated whether cross-sectional morphology and duct branching of human nipple obtained by X-ray dark-field imaging tomographic technique (XDFI-CT) could predict the likelihood of the presence of intraductal cancer into the nipple.

methodsA total of 51 nipple specimens were obtained from consecutive total mastectomies performed for breast cancer in Nagoya Medical Center. After reconstructing 3D images of the nipple using XDFI-CT, the cross-sectional images and the 3D arrangement of ducts were extracted. These cross-sectional images of ducts were classified into four patterns based on the status of the lumen without being informed of pathology results.

resultsOf the four patterns, the distended ducts with heterogenous content were highly correlated with the presence of ductal carcinoma in situ confirmed by histopathology. The total number of orifices identified in the 51 specimens was 1298, and 182 (14%) at the tip and 19 (1.5%) at least 5 mm depth from the tip were composed of two or more ducts.

conclusionsAnatomy of nipple ducts is essential to evaluate risk of local recurrence after nipple-sparing mastectomy because cancerous spread occurs within the duct of the same segment of the mammary duct-lobular system in the in situ stage. The 3D microscale anatomy of nipple ducts revealed by XDFI-CT provides useful information to assess the risk of breast cancer involvement at the preserved portion in nipple-sparing mastectomy.

Indexed as

Breast NeoplasmsCarcinoma, Ductal, BreastCarcinoma, Intraductal, NoninfiltratingFemaleHumansMastectomyNipplesX-RaysLactiferous ductsMicro-anatomyNippleRefraction-contrast computed tomographyX-ray dark-field imaging

Identifiers

PMID34386901
OpenAlexW3188963991

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.