Evidence map›Paper›PMID 34386861›Full record

ArticleJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology2022

"Global" cardiac atherosclerotic burden assessed by artificial intelligence-based versus manual segmentation in

Reza Piri, Lars Edenbrandt, Måns Larsson, Olof Enqvist, Sofie Skovrup, Kasper Karmark Iversen, Babak Saboury, Abass Alavi, Oke Gerke, Poul Flemming Høilund-Carlsen

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In one paragraph

Article in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Article
  3. Common carotid segmentation inClinical physiology and functional imaging · 2023
    Article
  4. Review
  5. "Global" cardiac atherosclerotic burden assessed by artificial intelligence-based versus manual segmentation inJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022
    Article
  6. Artificial intelligence-based quantification of cardiac 18F-sodium fluoride uptake.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022
    Article
  7. Automated artificial intelligence quantification of aortic atherosclerotic calcifications by 18F-sodium fluoride PET/CT.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022
    Article
  8. Article
  9. PET-Based Imaging withDiagnostics (Basel, Switzerland) · 2021
    Review
  10. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Reza PiriDepartment of Nuclear Medicine, Odense University Hospital, 5000, Odense C, Denmark. reza.piri2@rsyd.dk.ORCID 0000-0002-6379-3373
Lars EdenbrandtDepartment of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Måns LarssonEigenvision AB, Malmö, Sweden.
Olof EnqvistEigenvision AB, Malmö, Sweden.
Sofie SkovrupDepartment of Nuclear Medicine, Odense University Hospital, 5000, Odense C, Denmark.
Kasper Karmark IversenDepartment of Cardiology, Herlev and Gentofte Hospital, Copenhagen, Denmark.
Babak SabouryDepartment of Radiology, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.
Abass AlaviDepartment of Radiology, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.
Oke GerkeDepartment of Nuclear Medicine, Odense University Hospital, 5000, Odense C, Denmark.
Poul Flemming Høilund-CarlsenDepartment of Nuclear Medicine, Odense University Hospital, 5000, Odense C, Denmark.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundArtificial intelligence (AI) is known to provide effective means to accelerate and facilitate clinical and research processes. So in this study it was aimed to compare a AI-based method for cardiac segmentation in positron emission tomography/computed tomography (PET/CT) scans with manual segmentation to assess global cardiac atherosclerosis burden.

methodsA trained convolutional neural network (CNN) was used for cardiac segmentation in

resultsMean (± SD) values with manual vs. CNN-based segmentation were Vol 617.65 ± 154.99 mL vs 625.26 ± 153.55 mL (P = .21), SUVmean 0.69 ± 0.15 vs 0.69 ± 0.15 (P = .26), SUVmax 2.68 ± 0.86 vs 2.77 ± 1.05 (P = .34), and SUVtotal 425.51 ± 138.93 vs 427.91 ± 132.68 (P = .62). Limits of agreement were - 89.42 to 74.2, - 0.02 to 0.02, - 1.52 to 1.32, and - 68.02 to 63.21, respectively. Manual segmentation lasted typically 30 minutes vs about one minute with the CNN-based approach. The maximal deviation at manual re-segmentation was for the four parameters 0% to 0.5% with the same and 0% to 1% with different operators.

conclusionThe CNN-based method was faster and provided values for Vol, SUVmean, SUVmax, and SUVtotal comparable to the manually obtained ones. This AI-based segmentation approach appears to offer a more reproducible and much faster substitute for slow and cumbersome manual segmentation of the heart.

Indexed as

AtherosclerosisPositron Emission Tomography Computed TomographyArtificial IntelligenceHumansReproducibility of ResultsSodium FluorideSodium Fluorideartificial intelligenceatherosclerosisheartmicrocalcificationPET/CTsodium fluoride

Identifiers

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.