Evidence map›Paper›PMID 34386859›Full record

ArticleJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology2022

Quantitative myocardial perfusion response to adenosine and regadenoson in patients with suspected coronary artery disease.

Tanja Kero, Antti Saraste, Bo Lagerqvist, Jens Sörensen, Essi Pikkarainen, Mark Lubberink, Juhani Knuuti

Open access · hybridAbstract read
In one paragraph

Article in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. A simplified method to correct saturation of arterial input function for cardiac magnetic resonance first-pass perfusion imaging: validation with simultaneously acquired PET.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2023
    Article
  5. Review of cardiovascular imaging in the Journal of Nuclear Cardiology 2022: positron emission tomography, computed tomography, and magnetic resonance.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023
    Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Tanja KeroMedical Imaging Centre, Uppsala University Hospital, Uppsala, Sweden. tanja.kero@radiol.uu.se.
Antti SarasteTurku PET Centre, Turku, Finland.
Bo LagerqvistDepartment of Cardiology, Uppsala University Hospital, Uppsala, Sweden.
Jens SörensenMedical Imaging Centre, Uppsala University Hospital, Uppsala, Sweden.
Essi PikkarainenTurku PET Centre, Turku, Finland.
Mark Lubberink *Medical Physics, Uppsala University Hospital, Uppsala, Sweden.
Juhani Knuuti *Turku PET Centre, Turku, Finland.
Uppsala University Hospital · SETurku University Hospital · FITurku PET Centre · FIUppsala University · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe aim of the present study was to compare the quantitative flow responses of regadenoson against adenosine using cardiac

methodsHyperemic myocardial blood flow (MBF) after adenosine and regadenoson was compared using correlation and Bland-Altman analysis in 21 patients who underwent rest and adenosine

resultsGlobal mean (± SD) MBF values at rest and stress were 0.92 ± 0.27 and 2.68 ± 0.80 mL·g·min for the adenosine study and 0.95 ± 0.29 and 2.76 ± 0.79 mL·g·min for the regadenoson study (P = 0.55 and P = 0.49). The correlations between global and regional adenosine- and regadenoson-based stress MBF were strong (r = 0.80 and r = 0.77). The biases were small for both global and regional MBF comparisons (0.08 and 0.09 mL·min·g), but the limits of agreement were wide for stress MBF.

conclusionThe correlation between regadenoson- and adenosine-induced hyperemic MBF was strong but the agreement was only moderate indicating that established cut-off values for

Indexed as

Coronary Artery DiseaseHyperemiaMyocardial Perfusion ImagingAdenosineArteriesCoronary CirculationHumansPerfusionPositron-Emission TomographyPurinesPyrazolesWaterAdenosinePurinesPyrazolesregadenosonWaterModalitiesMyocardial blood flowVasodilators

Identifiers

PMID34386859
PMCPMC8873130
OpenAlexW3187562244

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.