Observational studyPediatric nephrology (Berlin, Germany)2022
The effect of continuous venovenous hemodiafiltration on amino acid delivery, clearance, and removal in children.
Observational study in Pediatric nephrology (Berlin, Germany), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.
- Growth after pediatric and neonatal acute kidney injury: a meta-analysis.Pediatric nephrology (Berlin, Germany) · 2025Pooled it
- Neonatal continuous kidney replacement therapy.Pediatric nephrology (Berlin, Germany) · 2026Review
- Pediatric tumor lysis syndrome: the nephrologist's role in prevention and management.Pediatric nephrology (Berlin, Germany) · 2026Review
- Continuous renal replacement therapy for septic shock: practicalities for a pediatric intensivist.European journal of pediatrics · 2026Review
- Feeding or Failing? Rethinking Nutrition Therapy in Pediatric Critical Care.Current nutrition reports · 2026Review
- Nutrition delivery in infants with kidney failure on extracorporeal kidney replacement therapy.Pediatric nephrology (Berlin, Germany) · 2026Article
- Prevalence of bone mineral disease in children with acute kidney disease on continuous kidney replacement therapy: a case-control study.Pediatric nephrology (Berlin, Germany) · 2026Article
- "Why won't the ammonia go down?": ammonia management while on continuous kidney replacement therapy.Pediatric nephrology (Berlin, Germany) · 2026Article
- Enhancing outcomes in pediatric populations with continuous renal replacement therapy: Current multidisciplinary strategies and innovations.Journal of intensive medicine · 2025Review
- Hyperglycemia and kidney outcomes in critically ill children and young adults on continuous kidney replacement therapy.Pediatric nephrology (Berlin, Germany) · 2025Observational
- Vitamin D and metabolic bone disease in prolonged continuous kidney replacement therapy: a prospective observational study.BMC nephrology · 2024Observational
- Advances in pediatric acute kidney injury pharmacology and nutrition: a report from the 26th Acute Disease Quality Initiative (ADQI) consensus conference.Pediatric nephrology (Berlin, Germany) · 2024Article
- Nutritional management of children with acute kidney injury-clinical practice recommendations from the Pediatric Renal Nutrition Taskforce.Pediatric nephrology (Berlin, Germany) · 2023Review
- Consensus-Based Recommendations on Priority Activities to Address Acute Kidney Injury in Children: A Modified Delphi Consensus Statement.JAMA network open · 2022Article
- The Neglected Price of Pediatric Acute Kidney Injury: Non-renal Implications.Frontiers in pediatrics · 2022Review
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn critically ill children with acute kidney injury (AKI), continuous kidney replacement therapy (CKRT) enables nutrition provision. The magnitude of amino acid loss during continuous venovenous hemodiafiltration (CVVHDF) is unknown and needs accurate quantification. We investigated the mass removal and clearance of amino acids in pediatric CVVHDF.
methodsThis is a prospective observational cohort study of patients receiving CVVHDF from August 2014 to January 2016 in the pediatric intensive care unit (PICU) of a tertiary children's hospital.
resultsFifteen patients (40% male, median age 2.0 (IQR 0.7, 8.0) years) were enrolled. Median PICU and hospital lengths of stay were 20 (9, 59) and 36 (22, 132) days, respectively. Overall survival to discharge was 66.7%. Median daily protein prescription was 2.00 (1.25, 2.80) g/kg/day. Median daily amino acid mass removal was 299.0 (174.9, 452.0) mg/kg body weight, and median daily amino acid mass clearance was 18.2 (13.5, 27.9) ml/min/m
conclusionCVVHDF prescription and related amino acid loss impact nutrition provision, with 14.6% of the prescribed protein removed. Current recommendations for protein provision for children requiring CVVHDF should be adjusted to compensate for circuit-related loss. A higher resolution version of the Graphical abstract is available as Supplementary information.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.