ArticlePediatric nephrology (Berlin, Germany)2022
Acute kidney injury and kidney recovery after cardiopulmonary bypass in children.
Article in Pediatric nephrology (Berlin, Germany), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- Incidence of acute kidney injury-associated mortality in hospitalized children: a systematic review and meta-analysis.BMC nephrology · 2025Pooled it
- Intraoperative Use of Sodium Bicarbonate Ringer's Solution Instead of Sodium Lactate Ringer's Solution to Reduce Endothelial Glycocalyx Degradation and Improve Postoperative Recovery During Cardiopulmonary Bypass Cardiac Surgery: A Single-Center Prospective Cohort Study.Drug design, development and therapy · 2024Trial
- Acute kidney diseases and disorders in children with bloodstream infection: frequency, predictors, and outcomes.Pediatric nephrology (Berlin, Germany) · 2026Article
- Interferon-γ and interleukin-17A associations with vascular dysfunction following paediatric cardiac surgery with cardiopulmonary bypass.Cardiology in the young · 2026Article
- The relevance of acute kidney injury in dehydrated children.Frontiers in pediatrics · 2025Review
- Article
- Outcomes of acute kidney injury continuum in children.Journal of nephrology · 2024Article
- Diuretic response after neonatal cardiac surgery: a report from the NEPHRON collaborative.Pediatric nephrology (Berlin, Germany) · 2024Article
- Acute Kidney Disease following Acute Kidney Injury in Children-A Retrospective Observational Cohort Study on Risk Factors and Outcomes.Journal of clinical medicine · 2024Article
- Persistent acute kidney injury and fluid accumulation with outcomes after the Norwood procedure: report from NEPHRON.Pediatric nephrology (Berlin, Germany) · 2024Article
- A proposed framework for advancing acute kidney injury risk stratification and diagnosis in children: a report from the 26th Acute Disease Quality Initiative (ADQI) conference.Pediatric nephrology (Berlin, Germany) · 2024Article
- Patient level factors increase risk of acute kidney disease in hospitalized children with acute kidney injury.Pediatric nephrology (Berlin, Germany) · 2023Article
- Kinetic Estimated Glomerular Filtration Rate in Predicting Paediatric Acute Kidney Disease.Journal of clinical medicine · 2023Article
- Etiology and outcomes of acute kidney disease in children: a cohort study.Clinical and experimental nephrology · 2023Article
- The Neglected Price of Pediatric Acute Kidney Injury: Non-renal Implications.Frontiers in pediatrics · 2022Review
- Update on prognosis driven classification of pediatric AKI.Frontiers in pediatrics · 2022Review
- Acute Kidney Disease in Hospitalized Pediatric Patients With Acute Kidney Injury in China.Frontiers in pediatrics · 2022Article
- Intraoperative hypotension is associated with postoperative acute kidney injury in infants undergoing cardiac surgery.Annals of pediatric cardiologyArticle
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAcute kidney injury (AKI) that improves in the pediatric intensive care unit (PICU) is associated with better outcomes compared to AKI that persists, but no study has investigated whether this also occurs in children undergoing cardiopulmonary bypass (CPB).
methodsA retrospective study of children ≤18 years who underwent CPB in three children's hospitals was conducted. Patients were classified into groups by kidney recovery after AKI according to Acute Disease Quality Initiative (ADQI) guidelines. Adjusted regression models evaluated associations between kidney recovery group and hospital outcomes.
resultsAmong 3620 children, AKI developed in 701 (19.4%): 610 transient AKI, 47 persistent AKI, and 44 acute kidney disease (AKD). Mortality increased with severity of kidney recovery group: 4.5% in the never developed AKI group, 8.9% in the transient AKI group, 25.5% in the persistent AKI group, and 31.8% in the AKD group (p <0.0001). In adjusted analysis, transient AKI (HR 1.4, CI 1.02, 2), persistent AKI (HR 22.4, CI 10.2, 49.2), and AKD (HR 3.7, CI 1.7, 7.9) had a greater hazard of mortality when compared to the never developed AKI group. Patients with transient AKI had a longer length of PICU stay than those with never developed AKI (HR 5.1, CI 2.9, 7.3).
conclusionsPatterns of kidney recovery after AKI were associated with worse PICU outcomes in children after CPB compared to those who did not develop AKI, even after rapid AKI recovery. Identification of factors that increase risk for these AKI patterns is necessary for prevention of AKI during CPB in children. A higher resolution version of the Graphical abstract is available as Supplementary information.
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