ArticleEClinicalMedicine2021
Dynamic alterations in linear growth and endocrine parameters in children with obesity and height reference values.
Article in EClinicalMedicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- IGF-1 and IGF-2 as Molecules Linked to Causes and Consequences of Obesity from Fetal Life to Adulthood: A Systematic Review.International journal of molecular sciences · 2024Pooled it
- Diagnosing Obesity in Korean Children Using BMI and Body Fat Percentage: Differences in Growth and Body Composition.Obesity facts · 2026Article
- Establishment of Thyroid Volume Reference Curves for Children in Xinjiang: An Exploration of Goiter Diagnosis and the Role of Iodine Nutrition.Biological trace element research · 2026Article
- The regulatory effects of growth hormone on adipose tissue at physiological and pathological levels and its relationship with obesity.International journal of obesity (2005) · 2026Review
- Blood DNA methylation of EIF5A and TGIF1 is associated with adipose tissue health and metabolic outcomes in obesity: a multi-cohort study.Clinical epigenetics · 2026Article
- Association Between Outdoor Physical Activity and Height Growth Velocity in Chinese Children Aged 9-15: A Secondary Analysis of a National Population-Based Cohort.Healthcare (Basel, Switzerland) · 2026Article
- Two Sides of a Coin: Molecular, metabolic, and Phenotypic Convergence in Pediatric Undernutrition and Obesity.Current obesity reports · 2026Review
- Exploring Autosomal Dominant Non-Syndromic Monogenic Obesity: From Genes to Therapy.Current issues in molecular biology · 2026Review
- Overweight & obesity epidemic, temporal trends and regional disparities in physical growth of Vietnamese children.Scientific reports · 2026Article
- Starting Age for Screening Metabolic Dysfunction-Associated Steatotic Liver Disease in Children Using Controlled Attenuation Parameter on Transient Elastography.Pediatric obesity · 2026Article
- Associations Between Weight-Related Measurements and Pubertal Markers in Norwegian Girls: The Bergen Growth Study 2.Journal of the Endocrine Society · 2025Article
- Endocrine consequences of childhood obesity: a narrative review.Frontiers in endocrinology · 2025Review
- Analysis of growth and development levels and influencing factors in children aged 3-12 years in a certain region: a cross-sectional study.Frontiers in public health · 2025Article
- Article
- Longitudinal analysis of epigenome-wide DNA methylation reveals novel loci associated with BMI change in East Asians.Clinical epigenetics · 2024Article
- Not Only Metabolic Complications of Childhood Obesity.Nutrients · 2024Review
- Height and Growth Velocity in Children and Adolescents Undergoing Obesity Treatment: A Prospective Cohort Study.The Journal of clinical endocrinology and metabolism · 2023Article
- A Digital Health Solution for Child Growth Monitoring at Home: Testing the Accuracy of a Novel "GrowthMonitor" Smartphone Application to Detect Abnormal Height and Body Mass Indices.Mayo Clinic proceedings. Digital health · 2023Article
- Health relevance of lowering postprandial glycaemia in the paediatric population through diet': results from a multistakeholder workshop.European journal of nutrition · 2023Review
- Article
Corrections and comments
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Authors and funding
13 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundObesity can affect linear growth of children but there is uncertainty regarding the dynamics and potential causes.
methodsIn the population-based LIFE Child and the obesity-enriched Leipzig Obesity Childhood cohorts (8,629 children, 37,493 measurements), recruited from 1999 to 2018 in Germany, we compared height, growth, and endocrine parameters between normal-weight and children with obesity (0-20 years). Derived from the independent German CrescNet registry (12,703 children) we generated height reference values specific for children with obesity (data collected from 1999 to 2020).
findingsChildren with obesity were significantly taller than normal-weight peers, differing at maximum by 7·6 cm (1·4 height, standard deviation scores or SDS) at age 6-8 years. Already at birth, children with obesity were slightly taller and thereafter had increased growth velocities by up to 1·2 cm/year. This growth acceleration was unrelated to parental height, but was accompanied by increased levels of insulin-like growth factor-1 (IGF-1), insulin and leptin. During puberty, children with obesity showed a catch-down in height SDS. The reduction in pubertal growth velocity by up to 25% coincided with a decrease in levels of IGF-1 (by 17%) and testosterone (by 62%) in boys and estradiol (by 37%) in girls. We confirmed these alterations in growth in the independent CrescNet cohort and furthermore provide height reference values for children with obesity for open access.
interpretationDynamics of linear growth are altered distinctively in different developmental phases in children with obesity. Early emergence before other profound comorbidities implies predisposition, environmental, and/or endocrine factors affecting growth in early life. Height reference values for children with obesity may enhance the precision of clinical health surveillance.
fundingGerman Research Foundation, German Diabetes Association, EU, ESF, ERDF, State of Saxony, ESPE, Hexal, Novo Nordisk, Pfizer Pharma.
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