Evidence map›Paper›PMID 34386732›Full record

ArticleiScience2021

Neutrophils require SKAP2 for reactive oxygen species production following C-type lectin and

Giang T Nguyen, Shuying Xu, Walter Adams, John M Leong, Stephen C Bunnell, Michael K Mansour, David B Sykes, Joan Mecsas

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

  1. Journal of medical microbiology · 2026
    Review
  2. Gain-of-function mutation inbioRxiv : the preprint server for biology · 2026
    Article
  3. INTEGRIN FUNCTION IN LEUKOCYTE-MEDIATED INFLAMMATION-ACTINOPATHIES IN IMMUNE DISEASES.Transactions of the American Clinical and Climatological Association · 2025
    Review
  4. Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Giang T NguyenGraduate Program in Immunology, Tufts Graduate School of Biomedical Sciences, Boston, MA 02111, USA.
Shuying XuDivision of Infectious Diseases, Massachusetts General Hospital, Boston, MA 02114, USA.
Walter AdamsDepartment of Molecular Biology and Microbiology, School of Medicine, Tufts University, Boston, MA 02111, USA.
John M LeongGraduate Program in Immunology, Tufts Graduate School of Biomedical Sciences, Boston, MA 02111, USA.
Stephen C BunnellGraduate Program in Immunology, Tufts Graduate School of Biomedical Sciences, Boston, MA 02111, USA.
Michael K MansourDivision of Infectious Diseases, Massachusetts General Hospital, Boston, MA 02114, USA.
David B SykesDepartment of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA.
Joan MecsasGraduate Program in Immunology, Tufts Graduate School of Biomedical Sciences, Boston, MA 02111, USA.
Tufts University · USHarvard University · USMassachusetts General Hospital · US

Funding

Training in Education and Critical Research SkillsK12GM074869 · NIGMS · TUFTS UNIVERSITY BOSTON · PI MOORE, CLAIRE L · 2006 to 2017
$8.5M
Initiation and regulation of antibacterial innate immunityR01AI113166 · NIAID · TUFTS UNIVERSITY BOSTON · PI MECSAS, JOAN C · 2014 to 2018
$2.4M
The role of spleen tyrosine kinase (syk) in neutrophil responses to pathogenic fungi.R01AI132638 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI MANSOUR, MICHAEL K · 2018 to 2021
$1.6M
Features of PMN Senescence that Lead to Susceptibility to Pneumococcal InfectionR21AG071268 · NIA · TUFTS UNIVERSITY BOSTON · PI LEONG, JOHN M, MECSAS, JOAN C · 2021 to 2022
$469k
NIAID NIH HHS R01 AI113166NIAID NIH HHS R01 AI132638NIA NIH HHS R21 AG071268NIGMS NIH HHS K12 GM074869
6 · The paper itself

Abstract

Signaling cascades converting the recognition of pathogens to efficient inflammatory responses by neutrophils are critical for host survival. SKAP2, an adaptor protein, is required for reactive oxygen species (ROS) generation following neutrophil stimulation by integrins, formyl peptide receptors, and for host defense against the Gram-negative bacterial pathogens,

Indexed as

Biological sciencescell biologyImmunologyMicrobiology

Identifiers

PMID34386732
PMCPMC8346660
OpenAlexW3186385964

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.