Evidence map›Paper›PMID 34386730›Full record

ArticleiScience2021

Dissecting the concordant and disparate roles of NDUFAF3 and NDUFAF4 in mitochondrial complex I biogenesis.

Anjaneyulu Murari, Shauna-Kay Rhooms, Christian Garcia, Tong Liu, Hong Li, Bibhuti Mishra, Cassie Deshong, Edward Owusu-Ansah

Open access · goldAbstract read
In one paragraph

Article in iScience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Using cryo-EM to understand the assembly pathway of respiratory complex I.Acta crystallographica. Section D, Structural biology · 2024
    Article
  6. Article
  7. Article
  8. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Anjaneyulu MurariDepartment of Physiology and Cellular Biophysics, Columbia University Irving Medical Center, New York, NY 10032, USA.
Shauna-Kay RhoomsDepartment of Physiology and Cellular Biophysics, Columbia University Irving Medical Center, New York, NY 10032, USA.
Christian GarciaDepartment of Physiology and Cellular Biophysics, Columbia University Irving Medical Center, New York, NY 10032, USA.
Tong LiuCenter for Advanced Proteomics Research, Department of Microbiology, Biochemistry and Molecular Genetics, Rutgers University - New Jersey Medical School, Newark, NJ 07103, USA.
Hong LiCenter for Advanced Proteomics Research, Department of Microbiology, Biochemistry and Molecular Genetics, Rutgers University - New Jersey Medical School, Newark, NJ 07103, USA.
Bibhuti MishraDepartment of Physiology and Cellular Biophysics, Columbia University Irving Medical Center, New York, NY 10032, USA.
Cassie DeshongDepartment of Physiology and Cellular Biophysics, Columbia University Irving Medical Center, New York, NY 10032, USA.
Edward Owusu-AnsahDepartment of Physiology and Cellular Biophysics, Columbia University Irving Medical Center, New York, NY 10032, USA.
Columbia University Irving Medical Center · USRutgers New Jersey Medical SchoolRutgers, The State University of New Jersey · US

Funding

Identifying Remote Regulators of Complex I Biogenesis in DrosophilaR35GM124717 · NIGMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI OWUSU-ANSAH, EDWARD · 2017 to 2021
$2.2M
Genetic Dissection of OXPHOS Assembly in Skeletal MusclesR21AR077312 · NIAMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI OWUSU-ANSAH, EDWARD · 2020 to 2021
$387k
NIAMS NIH HHS R21 AR077312NIGMS NIH HHS R35 GM124717
6 · The paper itself

Abstract

Distinct sub-assemblies (modules) of mitochondrial complex I (CI) are assembled with the assistance of CI Assembly Factors (CIAFs) through mechanisms that are incompletely defined. Here, using genetic analyses in

Indexed as

metabolic engineeringmolecular geneticsmolecular mechanism of gene regulation

Identifiers

PMID34386730
PMCPMC8346666
OpenAlexW3184948188

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.