Evidence map›Paper›PMID 34386727›Full record

ArticleiScience2021

White matter network of oral word reading identified by network-based lesion-symptom mapping.

Mingyang Li, Luping Song, Yumei Zhang, Zaizhu Han

Abstract read
In one paragraph

Article in iScience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Lesions Reveal Shared and Distinct Neurocognitive Bases of Oral Reading and Silent Word Recognition.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
  2. Review
  3. Article
  4. Article
  5. Stroke disconnectome decodes reading networks.Brain structure & function · 2022
    Article
  6. The Brain Connectome for Chinese Reading.Neuroscience bulletin · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Mingyang LiState Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing 100875, China.
Luping SongShenzhen University General Hospital, Department of Rehabilitation Medicine, Shenzhen 518055, China.
Yumei ZhangDepartment of Rehabilitation Medicine, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China.
Zaizhu HanState Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing 100875, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oral word reading is supported by a neural subnetwork that includes gray matter regions and white matter tracts connected by the regions. Traditional methods typically determine the reading-relevant focal gray matter regions or white matter tracts rather than the reading-relevant global subnetwork. The present study developed a network-based lesion-symptom mapping (NLSM) method to identify the reading-relevant global white matter subnetwork in 84 brain-damaged patients. The global subnetwork was selected among all possible subnetworks because its global efficiency exhibited the best explanatory power for patients' reading scores. This reading subnetwork was left lateralized and included 7 gray matter regions and 15 white matter tracts. Moreover, the reading subnetwork had additional explanatory power for the patients' reading performance after eliminating the effects of reading-related local regions and tracts. These findings refine the reading neuroanatomical architecture and indicate that the NLSM can be a better method for revealing behavior-specific subnetworks.

Indexed as

Behavioral neuroscienceBiological ScienceNeuroscience

Identifiers

PMID34386727
PMCPMC8346667

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.