Evidence map›Paper›PMID 34386717›Full record

ReviewCardiovascular endocrinology & metabolism2021

Salivary markers and coronavirus disease 2019: insights from cross-talk between the oral microbiome and pulmonary and systemic low-grade inflammation and implications for vascular complications.

Antoine AbdelMassih, Alaa A Hassan, Aya S Abou-Zeid, Aya Hassan, Engy Hussein, Mahenar Gadalla, Mahinour Hussein, Maryam A Eid, Maryam Elahmady, Nadine El Nahhas and 10 more

Open access · diamondAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cardiovascular endocrinology & metabolism, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 56% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 1 institution in 1 country.

Antoine AbdelMassihPediatric Cardiology Unit, Pediatrics' Department, Faculty of Medicine, Cairo University, Giza.
Alaa A HassanResearch Department, School of Oral and Dental Medicine, New Giza University, New Giza.
Aya S Abou-ZeidResearch Department, School of Oral and Dental Medicine, New Giza University, New Giza.
Aya HassanResearch Department, School of Oral and Dental Medicine, New Giza University, New Giza.
Engy HusseinResearch Department, School of Oral and Dental Medicine, New Giza University, New Giza.
Mahenar GadallaResearch Department, School of Oral and Dental Medicine, New Giza University, New Giza.
Mahinour HusseinResearch Department, School of Oral and Dental Medicine, New Giza University, New Giza.
Maryam A EidResearch Department, School of Oral and Dental Medicine, New Giza University, New Giza.
Maryam ElahmadyResearch Department, School of Oral and Dental Medicine, New Giza University, New Giza.
Nadine El NahhasResearch Department, School of Oral and Dental Medicine, New Giza University, New Giza.
Nadine EmadResearch Department, School of Oral and Dental Medicine, New Giza University, New Giza.
Nihal ZahraResearch Department, School of Oral and Dental Medicine, New Giza University, New Giza.
Nour AboushadiResearch Department, School of Oral and Dental Medicine, New Giza University, New Giza.
Nourhan IbrahimResearch Department, School of Oral and Dental Medicine, New Giza University, New Giza.
Sherouk MokhtarResearch Department, School of Oral and Dental Medicine, New Giza University, New Giza.
Habiba-Allah IsmailResearch Department, Faculty of Medicine, Cairo University, Cairo.
Nadine El-HusseinyResearch Department, Faculty of Medicine, Cairo University, Cairo.
Reham Khaled MoharamResidency Training Program of Plastic Surgery Department, Faculty of Medicine, Cairo University, Giza, Egypt.
Esraa MenshaweyResearch Department, Faculty of Medicine, Cairo University, Cairo.
Rahma MenshaweyResearch Department, Faculty of Medicine, Cairo University, Cairo.
Cairo University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To date, coronavirus disease 2019 (COVID-19) has affected over 6.2 million individuals worldwide, including 1.46 million deaths. COVID-19 complications are mainly induced by low-grade inflammation-causing vascular degeneration. There is an increasing body of evidence that suggests that oral dysbiotic taxa are associated with worse prognosis in COVID-19 patients, especially the Prevotella genus, which was retrieved from nasopharyngeal and bronchoalveolar lavage samples in affected patients. Oral dysbiosis may act by increasing the likelihood of vascular complications through low-grade inflammation, as well as impairing respiratory mucosal barrier mechanisms against SARS-CoV-2. Salivary markers can be used to reflect this oral dysbiosis and its subsequent damaging effects on and the lungs and vasculature. Salivary sampling can be self-collected, and is less costly and less invasive, and thus may be a superior option to serum markers in risk stratification of COVID-19 patients. Prospective studies are needed to confirm such hypothesis. Video Abstract: http://links.lww.com/CAEN/A28.

Indexed as

COVID-19cross-talkimmune and metabolic dysregulationoral dysbiosisPrevotellavascular complications

Identifiers

PMID34386717
PMCPMC8352626
OpenAlexW3122182654

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.