Evidence map›Paper›PMID 34386700›Full record

ArticleMediterranean journal of rheumatology2021

Spectrum of Myelitis in Systemic Lupus Erythematosus: Experience from a Single Tertiary Care Centre over 25 Years.

Pankti Mehta, Latika Gupta, Hafis Muhammed, Durga P Misra, Able Lawrence, Vikas Agarwal, Amita Aggarwal, Ramnath Misra

Open access · diamondAbstract read
In one paragraph

Article in Mediterranean journal of rheumatology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. MRI-Negative Central Nervous System SLE: A Unique Case Report.Annals of Indian Academy of Neurology · 2025
    Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Pankti MehtaDepartment of Clinical Immunology and Rheumatology, SGPGIMS, Lucknow, India.
Latika GuptaDepartment of Clinical Immunology and Rheumatology, SGPGIMS, Lucknow, India.
Hafis MuhammedDepartment of Clinical Immunology and Rheumatology, SGPGIMS, Lucknow, India.
Durga P MisraDepartment of Clinical Immunology and Rheumatology, SGPGIMS, Lucknow, India.
Able LawrenceDepartment of Clinical Immunology and Rheumatology, SGPGIMS, Lucknow, India.
Vikas AgarwalDepartment of Clinical Immunology and Rheumatology, SGPGIMS, Lucknow, India.
Amita AggarwalDepartment of Clinical Immunology and Rheumatology, SGPGIMS, Lucknow, India.
Ramnath MisraDepartment of Clinical Immunology and Rheumatology, SGPGIMS, Lucknow, India.
Sanjay Gandhi Post Graduate Institute of Medical Sciences · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundInflammatory myelitis rarely occurs in Systemic Lupus Erythematosus (SLE).

methodsMedical records from a tertiary care centre in India (1989-2018) were reviewed to identify patients with myelitis in SLE and their clinical characteristics and outcomes were compared with two matching comparators drawn from adjacent hospital registration numbers in the SLE database.

resultsTen patients had myelitis from a cohort of 1768 patients with SLE. Myelitis was the first manifestation of lupus in 7 (70%). Cervicothoracic cord was most frequent site of involvement. ANA was negative at onset in 2 cases. One of 4 was positive for Anti-Aquaporin 4 antibody. Four had relapsing disease (16 events) with a median time to relapse of 0.65 years (0.3- 7 years). All cases received steroid sparing agents over the follow-up duration (78.5 patient years). Lupus nephritis (20% vs. 75%, p=0.004) and haematologic manifestations (0 vs. 25%, p=0.02) were less common. Higher frequency of anti-Ro antibodies was noted in the group with myelitis (p=0.05).

conclusionMyelitis can be a presenting feature of SLE with lupus nephritis and hematologic involvement being rare. Relapses are common that mandate long-term immunosuppression.

Indexed as

demyelinating syndromeslupusmyelitisneuromyelitis optica spectrum disordersneuropsychiatric lupusrituximabSLE

Identifiers

PMID34386700
PMCPMC8314885
OpenAlexW3159385757

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.