Evidence map›Paper›PMID 34386698›Full record

ReviewMediterranean journal of rheumatology2021

Cardiovascular Magnetic Resonance Reveals Cardiac Pathophysiology in Autoimmune Rheumatic Diseases.

George Markousis-Mavrogenis, Petros P Sfikakis, Loukia Koutsogeorgopoulou, Theodoros Dimitroulas, Gikas Katsifis, Aikaterini Giannakopoulou, Paraskevi Voulgari, Genovefa Kolovou, George D Kitas, Sophie I Mavrogeni

Open access · diamondAbstract readReview
In one paragraph

Review in Mediterranean journal of rheumatology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.7field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 8 institutions in 2 countries.

George Markousis-MavrogenisOnassis Cardiac Surgery Center, Athens, Greece.
Petros P SfikakisJoint Rheumatology, Laikon Hospital, Athens, Greece.
Loukia KoutsogeorgopoulouDepartment of Pathophysiology, Laikon Hospital, National Kapodistrian University of Athens, Athens, Greece.
Theodoros DimitroulasDepartment of Internal Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Gikas KatsifisNaval Hospital, Athens, Greece.
Aikaterini GiannakopoulouAgia Sophia Children's Hospital, Athens, Greece.
Paraskevi VoulgariRheumatology Department, University of Ioannina, Ioannina, Greece.
Genovefa KolovouOnassis Cardiac Surgery Center, Athens, Greece.
George D KitasArthritis Research UK Epidemiology Unit, Manchester University, Manchester, United Kingdom.
Sophie I MavrogeniOnassis Cardiac Surgery Center, Athens, Greece.
Onassis Cardiac Surgery Center · GRAristotle University of Thessaloniki · GRAthens Naval & Veterans Hospital · GRChildren's Hospital Agia Sophia · GRLaiko General Hospital of Athens · GRNational and Kapodistrian University of Athens · GRUniversity of Ioannina · GRUniversity of Manchester · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

aimsThe high incidence of cardiovascular disease (CVD) in patients with autoimmune rheumatic diseases (ARDs) is the main driver towards increased mortality in this patient group. Cardiovascular magnetic resonance (CMR) can non-invasively and robustly detect CVD in ARD patients at an early stage of development. The review summarises the diagnostic information provided by CMR in ARD patients. SUMMARY: CMR uses a strong magnetic field combined with radio-frequency pulses (pulse sequences) to generate images. Firstly, balanced steady-state free precession (bSSFP) can be used for evaluating cardiac anatomy, mass, wall motion, atrial/ventricular function. Secondly, T2-weighted imaging (T2-W) can be used for oedema detection, which appears as a high signal intensity area on STIR (short tau inversion recovery) images. T2 mapping is a newer T2-W technique that can provide more optimal identification of myocardial oedema. Lastly, late gadolinium enhanced (LGE) T1-W images, taken 15 min. after injection of contrast agent, allow the detection of myocardial replacement fibrosis, which appears as a bright area in a background of black myocardium. However, LGE has inherent disadvantages for the assessment of diffuse myocardial fibrosis. Therefore, T1 mapping and extracellular volume fraction (ECV) have been developed to quantify diffuse myocardial fibrosis.

resultsAlthough multicentre studies are still missing, the CMR parameters have been extensively applied for the identification of oedema/fibrosis and treatment decision making in ARDs.

conclusionsTissue characterisation with CMR allows early and robust identification of CVD in ARD patients and contributes to personalized management in the patients.

Indexed as

Cardiovascular magnetic resonancecoronary artery diseasemyocardial inflammationmyocardial perfusionfibrosisvasculitis

Identifiers

PMID34386698
PMCPMC8314875
OpenAlexW3162759269

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.