Evidence map›Paper›PMID 34386588›Full record

ArticleBiology methods & protocols2021

Optimization and biological validation of an

Julián Ernesto Nicolás Gulin, Daniela Marisa Rocco, Victoria Alonso, Pamela Cribb, Jaime Altcheh, Facundo García-Bournissen

Open access · goldAbstract read
In one paragraph

Article in Biology methods & protocols, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Reporter genes and transgenicFrontiers in medicine · 2025
    Review
  3. Identification of novel bromodomain inhibitors ofAntimicrobial agents and chemotherapy · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Julián Ernesto Nicolás GulinInstituto Multidisciplinario de Investigaciones en Patologías Pediátricas (IMIPP), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET)-Gobierno de la Ciudad de Buenos Aires (GCBA), Gallo 1330 (C1425EFD), Buenos Aires, Argentina.
Daniela Marisa RoccoInstituto Multidisciplinario de Investigaciones en Patologías Pediátricas (IMIPP), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET)-Gobierno de la Ciudad de Buenos Aires (GCBA), Gallo 1330 (C1425EFD), Buenos Aires, Argentina.
Victoria AlonsoInstituto de Biología Molecular y Celular de Rosario, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario (IBR-CONICET-UNR), Suipacha 531 (2000), Rosario, Argentina.
Pamela CribbInstituto de Biología Molecular y Celular de Rosario, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario (IBR-CONICET-UNR), Suipacha 531 (2000), Rosario, Argentina.
Jaime AltchehInstituto Multidisciplinario de Investigaciones en Patologías Pediátricas (IMIPP), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET)-Gobierno de la Ciudad de Buenos Aires (GCBA), Gallo 1330 (C1425EFD), Buenos Aires, Argentina.
Facundo García-BournissenInstituto Multidisciplinario de Investigaciones en Patologías Pediátricas (IMIPP), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET)-Gobierno de la Ciudad de Buenos Aires (GCBA), Gallo 1330 (C1425EFD), Buenos Aires, Argentina.
Consejo Nacional de Investigaciones Científicas y Técnicas · ARHospital General de Niños Ricardo Gutierrez · ARInstituto de Biología Molecular y Celular de Rosario · AR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

There is an urgent need to develop safer and more effective drugs for Chagas disease, as the current treatment relies on benznidazole (BZ) and nifurtimox (NFX). Using the

Indexed as

high-throughput screeningin vitro drug screeningTrypanosoma cruzi

Identifiers

PMID34386588
PMCPMC8355463
OpenAlexW3179690541

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.