Evidence map›Paper›PMID 34386578›Full record

ArticleTransplantation direct2021

Dual Versus Single Oxygenated Hypothermic Machine Perfusion of Porcine Livers: Impact on Hepatobiliary and Endothelial Cell Injury.

Yvonne de Vries, Isabel M A Brüggenwirth, Shanice A Karangwa, Fien A von Meijenfeldt, Otto B van Leeuwen, Laura C Burlage, Iris E M de Jong, Annette S H Gouw, Vincent E de Meijer, Ton Lisman and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Transplantation direct, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 31 citations in OpenAlex.

  1. Trial
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Review
  12. Observational
  13. Prolonged preservation by hypothermic machine perfusion facilitates logistics in liver transplantation: A European observational cohort study.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2022
    Observational
  14. Review
  15. A Review of Machine Perfusion Strategies in Liver Transplantation.Journal of clinical and experimental hepatology
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Yvonne de VriesSurgical Research Laboratory, Department of Surgery, University Medical Center Groningen, Groningen, the Netherlands.
Isabel M A BrüggenwirthSurgical Research Laboratory, Department of Surgery, University Medical Center Groningen, Groningen, the Netherlands.
Shanice A KarangwaSurgical Research Laboratory, Department of Surgery, University Medical Center Groningen, Groningen, the Netherlands.
Fien A von MeijenfeldtSurgical Research Laboratory, Department of Surgery, University Medical Center Groningen, Groningen, the Netherlands.
Otto B van LeeuwenSurgical Research Laboratory, Department of Surgery, University Medical Center Groningen, Groningen, the Netherlands.
Laura C BurlageSurgical Research Laboratory, Department of Surgery, University Medical Center Groningen, Groningen, the Netherlands.
Iris E M de JongSurgical Research Laboratory, Department of Surgery, University Medical Center Groningen, Groningen, the Netherlands.
Annette S H GouwDepartment of Pathology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Vincent E de MeijerSection of Hepatobiliary Surgery and Liver Transplantation, Department of Surgery, University Medical Center Groningen, Groningen, the Netherlands.
Ton LismanSurgical Research Laboratory, Department of Surgery, University Medical Center Groningen, Groningen, the Netherlands.
Robert J PorteSection of Hepatobiliary Surgery and Liver Transplantation, Department of Surgery, University Medical Center Groningen, Groningen, the Netherlands.
University Medical Center Groningen · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHypothermic oxygenated machine perfusion (HOPE) reduces ischemia-reperfusion injury of donor livers and is increasingly used in clinical transplantation. However, it remains unclear whether perfusion via the portal vein alone (HOPE) or via both the portal vein and hepatic artery (dual HOPE or DHOPE) is superior.

methodsTwelve porcine livers donated after circulatory death were randomized for 2 h of HOPE (n = 6) or DHOPE (n = 6), followed by 4 h of warm reperfusion with whole blood, to mimic transplantation. Hepatobiliary and endothelial cell function and injury markers were determined in perfusate and bile samples. Biopsies of bile ducts, hepatic arteries, and liver parenchyma were collected to assess histological damage and the expression of endothelial protective genes (KLF-2, eNOS, ET-1, CD31, VWF, VEGF-A).

resultsThere were no differences in hepatobiliary function and injury after warm reperfusion between the groups, apart from a 2-fold lower concentration of alanine aminotransferase in the perfusate (

conclusionsThis study did not reveal major differences in hepatobiliary or endothelial function and injury after preservation by single or dual HOPE of porcine livers donated after circulatory death.

Identifiers

PMID34386578
PMCPMC8354629
OpenAlexW3190972321

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.