ArticleInternational journal of cardiology. Heart & vasculature2021
Global longitudinal strain as a prognostic marker in cardiac resynchronisation therapy: A systematic review.
Article in International journal of cardiology. Heart & vasculature, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Synergistic Value of Combined Electrical, Structural, and Functional Response Metrics in the Prediction of Long-Term Event-Free Survival After Cardiac Resynchronization Therapy.Reviews in cardiovascular medicine · 2026Article
- Associations between cardiometabolic traits and diabetic cardiomyopathy: an imaging-based analysis.Acta diabetologica · 2026Article
- Left ventricular functional outcomes in His vs. left bundle branch area pacing: Is lead distance important in LBBAP implantation?BMC cardiovascular disorders · 2026Observational
- Prospective Study on the Evaluation of Echocardiographic Parameters as Predictors of a Positive Response to Cardiac Resynchronization Therapy in a Tertiary Care Hospital in Mexico.Journal of clinical medicine · 2026Article
- Predictors of patient-perceived functional improvement after cardiac resynchronization therapy: a real-world multi-dimensional analysis of clinical, imaging, and ECG predictors.Frontiers in cardiovascular medicine · 2026Article
- Clinical Applications of Speckle-Tracking Echocardiography in Heart Failure: From Diagnosis to Prognostication.International journal of heart failure · 2025Review
- Echocardiographic imaging in patients with conduction system pacing.Cardiovascular ultrasound · 2025Review
- Myocarditis with preserved left ventricular ejection fraction in-hospital convalescent phase: insights from CMR and myocardial strain analysis.Frontiers in cardiovascular medicine · 2025Article
- Heart Rate Variability and Global Longitudinal Strain for Prognostic Evaluation and Recovery Assessment in Conservatively Managed Post-Myocardial Infarction Patients.Journal of clinical medicine · 2024Article
- Cardiac CT in CRT as a Singular Imaging Modality for Diagnosis and Patient-Tailored Management.Journal of clinical medicine · 2023Review
- Tropoelastin Improves Post-Infarct Cardiac Function.Circulation research · 2023Article
- The saga of dyssynchrony imaging: Are we getting to the point.Frontiers in cardiovascular medicine · 2023Review
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeCardiac resynchronisation therapy (CRT) has proven mortality benefits for heart failure patients with moderate to severe systolic left ventricular dysfunction and evidence of a left bundle branch block. Determining responders to this therapy can be difficult due to the presence of myocardial fibrosis and scar. Left ventricular global longitudinal strain (LV GLS) is a robust and sensitive measure of myocardial function and fibrosis that has significant prognostic value for a plethora of cardiac pathologies. Our aim was to perform a systematic review of the value of LV GLS for predicting outcomes in patients undergoing CRT.
methodsA systematic review of the literature was conducted according to the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) protocol for reporting on systematic reviews and meta-analyses. An electronic search of all English, adult publications in EMBASE, MEDLINE/PubMed and the Cochrane Database of Systematic reviews was undertaken.
resultsThe search yielded, 9 studies that included 3,981 patients with symptomatic heart failure, undergoing CRT implantation with LV GLS utilised as a predictor of all-cause mortality, cardiovascular death, rehospitalisation, LVAD implantation/ heart transplantation or left ventricular reverse remodelling. Significant heterogeneity was observed in study outcome measures, included populations, LV-GLS cut-offs and follow-up definitions, resulting in the inability to reliably conduct a meta-analyses. Overall, pre-CRT LV GLS was found to be a predictor of outcome post CRT insertion.
conclusionsIn conclusion, all studies implied that incrementally abnormal baseline LV GLS pre-CRT implantation was associated with a long term poorer outcome.
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