ArticleAlzheimer's & dementia (Amsterdam, Netherlands)2021
Polygenic score modifies risk for Alzheimer's disease in
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Article in Alzheimer's & dementia (Amsterdam, Netherlands), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18citing papers in PubMed
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Who cites it
18 citing papers in PubMed.
- Polygenicity and APOE ε4 shape response to intervention in mild cognitive impairment.Alzheimer's research & therapy · 2025Trial
- Rare extreme polygenic risk scores strongly indicate Alzheimer's disease risk.medRxiv : the preprint server for health sciences · 2026Article
- Associations between polygenic risk scores for Alzheimer's disease and postoperative delirium risk.Journal of Alzheimer's disease : JAD · 2026Article
- Early onset Alzheimer's disease with V180I variant of prion protein gene and a family history of dementia: a case report.BMC neurology · 2026Article
- Genetic Burden andJournal of personalized medicine · 2026Article
- Rare and novel genetic variants in sporadic and familial Alzheimer's disease: insights from the first Saudi cohort.Frontiers in aging · 2026Article
- Alzheimer's disease: genetic background in the era of next-generation sequencing technologies.Brain communications · 2026Review
- Blood biomarker profiles in young-onset neurocognitive disorders: A cohort study.The Australian and New Zealand journal of psychiatry · 2025Article
- Apolipoprotein E and Alzheimer's Disease in Italian Population: Systematic Review and Meta-Analysis.Brain sciences · 2024Review
- Multifaceted roles of APOE in Alzheimer disease.Nature reviews. Neurology · 2024Review
- Resistance and Resilience to Alzheimer's Disease.Cold Spring Harbor perspectives in medicine · 2024Review
- Multi-Omic Blood Biomarkers as Dynamic Risk Predictors in Late-Onset Alzheimer's Disease.International journal of molecular sciences · 2024Review
- Testing a polygenic risk score for morphological microglial activation in Alzheimer's disease and aging.medRxiv : the preprint server for health sciences · 2023Article
- An interpretable Alzheimer's disease oligogenic risk score informed by neuroimaging biomarkers improves risk prediction and stratification.Frontiers in aging neuroscience · 2023Article
- Testing a Polygenic Risk Score for Morphological Microglial Activation in Alzheimer's Disease and Aging.Journal of Alzheimer's disease : JAD · 2023Article
- Neurocognitive trajectory and proteomic signature of inherited risk for Alzheimer's disease.PLoS genetics · 2022Article
- Polygenic Risk Scores in Alzheimer's Disease Genetics: Methodology, Applications, Inclusion, and Diversity.Journal of Alzheimer's disease : JAD · 2022Review
- Polygenic score modifies risk for Alzheimer's disease inAlzheimer's & dementia (Amsterdam, Netherlands) · 2021Article
Corrections and comments
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Authors and funding
17 authors.
Aamira J HuqDepartment of Epidemiology and Preventive Medicine School of Public Health and Preventive Medicine Monash University Melbourne Australia.
Brian Fulton-HowardNash Family Department of Neuroscience and Ronald Loeb Center for Alzheimer's Disease Icahn School of Medicine at Mount Sinai New York New York USA.
Moeen RiazDepartment of Epidemiology and Preventive Medicine School of Public Health and Preventive Medicine Monash University Melbourne Australia.
Simon LawsCollaborative Genomics Group Centre of Excellence for Alzheimer's Disease Research and Care School of Medical and Health Sciences Edith Cowan University Joondalup Western Australia Australia.
Robert SebraDepartments of Neurology and Genetics and Genomic Sciences Icahn School of Medicine at Mount Sinai New York New York USA.
Joanne RyanDepartment of Epidemiology and Preventive Medicine School of Public Health and Preventive Medicine Monash University Melbourne Australia.
Alzheimer's Disease Genetics Consortium
Alan E RentonNash Family Department of Neuroscience and Ronald Loeb Center for Alzheimer's Disease Icahn School of Medicine at Mount Sinai New York New York USA.
Alison M GoateNash Family Department of Neuroscience and Ronald Loeb Center for Alzheimer's Disease Icahn School of Medicine at Mount Sinai New York New York USA.
Colin L MastersThe Florey Institute University of Melbourne Parkville Victoria Australia.
Elsdon StoreyDepartment of Epidemiology and Preventive Medicine School of Public Health and Preventive Medicine Monash University Melbourne Australia.
Raj C ShahDepartment of Family Medicine and Rush Alzheimer's Disease Center Rush University Medical Center Chicago Illinois USA.
Anne MurrayBerman Center for Outcomes and Clinical Research Hennepin Healthcare Research Institute Hennepin Healthcare and University of Minnesota Minneapolis Minnesota USA.
John McNeilDepartment of Epidemiology and Preventive Medicine School of Public Health and Preventive Medicine Monash University Melbourne Australia.
Ingrid WinshipDepartment of Genomic Medicine Royal Melbourne Hospital Melbourne Victoria Australia.
Paul A JamesDepartment of Genomic Medicine Royal Melbourne Hospital Melbourne Victoria Australia.
Paul LacazeDepartment of Epidemiology and Preventive Medicine School of Public Health and Preventive Medicine Monash University Melbourne Australia.
Funding
National Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD)U24AG021886 · NIA · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI TATIANA M. FOROUD · 2002 to 2026
$119.8MNATIONAL ALZHEIMERS COORDINATING CENTER (NACC)U01AG016976 · NIA · UNIVERSITY OF WASHINGTON · PI KUKULL, WALTER ANTHONY · 1999 to 2020
$72.8MASPirin in Reducing Events in the ElderlyU01AG029824 · NIA · HENNEPIN HEALTHCARE RESEARCH INSTITUTE · PI MCNEIL, JOHN JAMES, MURRAY, ANNE M · 2009 to 2018
$64.6MAlzheimer's Disease Genetics ConsortiumU01AG032984 · NIA · UNIVERSITY OF PENNSYLVANIA · PI SCHELLENBERG, GERARD DAVID · 2009 to 2024
$60.4MTHE NIA GENETICS OF ALZHEIMER'S DISEASE DATA STORAGE SITEU24AG041689 · NIA · UNIVERSITY OF PENNSYLVANIA · PI LI-SAN WANG · 2012 to 2026
$42.3MGenome Wide associate analysis of Alzheimer's DiseaseRC2AG036528 · NIA · UNIVERSITY OF PENNSYLVANIA · PI SCHELLENBERG, GERARD DAVID · 2009 to 2010
$5.4MGenomic approach to identification of microglial networks involved in Alzheimer’s disease riskU01AG058635 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI GOATE, ALISON M · 2018 to 2022
$4.8MIdentification and characterization of AD risk networks using multi-dimensional "omics" dataU01AG052411 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI CRUCHAGA, CARLOS, GOATE, ALISON M · 2016 to 2020
$4.5MBig Omics Data Engine 2 SupercomputerS10OD026880 · OD · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KOVATCH, PATRICIA · 2019 to 2019
$2.0MNIA NIH HHS RC2 AG036528NIA NIH HHS U01 AG016976NIA NIH HHS U01 AG029824NIA NIH HHS U01 AG032984NIA NIH HHS U01 AG052411NIA NIH HHS U01 AG058635NIA NIH HHS U24 AG021886NIA NIH HHS U24 AG041689NIH HHS S10 OD026880
Abstract
introductionDiversity in cognition among apolipoprotein E (
methodsWe evaluated a phenotypic extreme polygenic risk score (PRS) for AD between cognitively healthy
resultsThe PRS for AD was significantly higher in DISCUSSION: A PRS for AD contributes to modified cognitive expression of the
Indexed as
Alzheimer's diseaseAlzheimer's disease dementiaapolipoprotein Edementia resiliencegenetic modifierspolygenic risk score
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.