Evidence map›Paper›PMID 34386420›Full record

ArticleFrontiers in oncology2021

Case Report: Rare Case of Synchronous Neck Metastasis From Metachronous Bilateral Renal Cell Carcinoma.

Jun Dai, Chen Fang, Xiaoqun Yang, Xin Huang, Wei He, Chenghe Wang, Juping Zhao, Fukang Sun

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 54% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Jun DaiDepartment of Urology, School of Medicine, Ruijin Hospital, Shanghai Jiao Tong University, Shanghai, China.
Chen FangDepartment of Urology, School of Medicine, Ruijin Hospital, Shanghai Jiao Tong University, Shanghai, China.
Xiaoqun YangDepartment of Pathology, School of Medicine, Ruijin Hospital, Shanghai Jiao Tong University, Shanghai, China.
Xin HuangDepartment of Urology, School of Medicine, Ruijin Hospital, Shanghai Jiao Tong University, Shanghai, China.
Wei HeDepartment of Urology, School of Medicine, Ruijin Hospital, Shanghai Jiao Tong University, Shanghai, China.
Chenghe WangDepartment of Urology, School of Medicine, Ruijin Hospital, Shanghai Jiao Tong University, Shanghai, China.
Juping ZhaoDepartment of Urology, School of Medicine, Ruijin Hospital, Shanghai Jiao Tong University, Shanghai, China.
Fukang SunDepartment of Urology, School of Medicine, Ruijin Hospital, Shanghai Jiao Tong University, Shanghai, China.
Ruijin Hospital · CNShanghai Jiao Tong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Renal cell carcinoma (RCC) is a malignant tumor that can metastasize easily. Hence, many patients have already developed metastasis when they are diagnosed. It is also one of the most common tumors that metastasize to the head and neck through extranodal disease. Herein, we reported a case of a 53-year-old man with cervical metastasis from bilateral RCC. Interestingly, whole exome sequencing (WES) and clonal evolution analysis revealed that bilateral renal tumor lesions and neck metastases (squamous cell carcinoma) share the same subclones and a large number of gene variants, while the pathological morphology is different (left nephrotic foci, a mixed pattern of mucinous tubular and spindle cell carcinoma (MTSCC) with papillary adenoma; right renal foci, papillary renal cell carcinoma (PRCC)). This was first reported in RCCs to the best of our knowledge. This case suggests that genotype analysis can be a powerful supplementary examination for clinical histopathological diagnosis. Gene detection has great significance for the accurate diagnosis and treatment of RCC metastasis or multiple lesions.

Indexed as

bilateralcase reportgene detectionMTSCCneck metastasisPRCC

Identifiers

PMID34386420
PMCPMC8354027
OpenAlexW3185768529

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.