ArticleJournal of oral biology and craniofacial research
Salivary melatonin is depleted in patients with dental caries due to the elevated oxidative stress.
Article in Journal of oral biology and craniofacial research. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 6 citations in OpenAlex.
- Effects of salivary proteinase 3 and oxidative stress markers on secondary caries following pit-and-fissure sealants in patients with S-ECC.Annals of medicine and surgery (2012) · 2026Article
- Article
- Sleep and its association with dental caries or myopia in first graders.Nursing open · 2024Article
- Association between sleep duration and dental caries in a nationally representative U.S. population.BMC oral health · 2023Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo determine salivary melatonin and malondialdehyde levels in individuals with and without dental caries. MATERIALS AND
methodsSaliva samples were collected in a fasting state from patients with active dental caries (n = 16) and patients without dental caries (n = 16). Melatonin was measured in the samples using a commercially available ELISA kit and malondialdehyde was assayed using a standardized spectrophotometric method.
resultsThe salivary melatonin levels were significantly lower (p < 0.01) in patients with active dental caries than patients without dental caries, while the salivary malondialdehyde values were significantly higher (p < 0.01) in patients with active dental caries than patients without dental caries. The binary logistic regression analysis revealed a negative correlation (-0.513) between the salivary melatonin and malondialdehyde levels which was statistically significant (p < 0.042) in the patient group with active dental caries, while no such relationship could be demonstrated in the patient group without dental caries.
conclusionMelatonin depletion and augmented malondialdehyde levels potentially indicate that the endogenous melatonin has been utilized to counter the oxidative stress-induced during the initiation and progression of dental caries. Further research could explore the potential use of exogenous melatonin supplementation as a preventive and therapeutic measure for dental caries.
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