Evidence map›Paper›PMID 34386332›Full record

ArticleActa pharmaceutica Sinica. B2021

Gold nanorods-mediated efficient synergistic immunotherapy for detection and inhibition of postoperative tumor recurrence.

Yingying Zhang, Tiange Wang, Yu Tian, Chaonan Zhang, Kun Ge, Jinchao Zhang, Jin Chang, Hanjie Wang

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta pharmaceutica Sinica. B, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 33 citations in OpenAlex.

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  13. Circulating tumor cells: biology and clinical significance.Signal transduction and targeted therapy · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Yingying ZhangSchool of Life Sciences, Tianjin University, Tianjin 300072, China.
Tiange WangSchool of Life Sciences, Tianjin University, Tianjin 300072, China.
Yu TianSchool of Life Sciences, Tianjin University, Tianjin 300072, China.
Chaonan ZhangSchool of Life Sciences, Tianjin University, Tianjin 300072, China.
Kun GeCollege of Chemistry & Environmental Science, Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of Education, Chemical Biology Key Laboratory of Hebei Province, Hebei University, Baoding 071002, China.
Jinchao ZhangCollege of Chemistry & Environmental Science, Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of Education, Chemical Biology Key Laboratory of Hebei Province, Hebei University, Baoding 071002, China.
Jin ChangSchool of Life Sciences, Tianjin University, Tianjin 300072, China.
Hanjie WangSchool of Life Sciences, Tianjin University, Tianjin 300072, China.
Tianjin University · CNHebei University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tumor recurrence after surgery is the main cause of treatment failure. However, the initial stage of recurrence is not easy to detect, and it is difficult to cure in the late stage. In order to improve the life quality of postoperative patients, an efficient synergistic immunotherapy was developed to achieve early diagnosis and treatment of post-surgical tumor recurrence, simultaneously. In this paper, two kinds of theranostic agents based on gold nanorods (AuNRs) platform were prepared. AuNRs and quantum dots (QDs) in one agent was used for the detection of carcinoembryonic antigen (CEA), using fluorescence resonance energy transfer (FRET) technology to indicate the occurrence of

Indexed as

AFP, alpha fetoproteinAgNO3, silver nitrateanti-PDL1, anti-programmed cell death-ligand 1AP1-QDs, CEA aptamer-modified CdTe QDsAP2-AuNRs, and interferon-γAP2-AuNRs, CEA aptamer-modified AuNRsaPDL1-LA, anti-PDL1-modified liposomes encapsulated AuNRsaPDL1-LAI, anti-PDL1-modified liposomes loaded with ICG and encapsulated AuNRsaPDL1-LA+NIR, anti-PDL1-modified liposomes encapsulated AuNRs with near-infrared irradiationAuNRs, gold nanorodsCA, cancer antigenCarcinoembryonic antigenCdCl2, cadmium chlorideCdTe QDs, CdTe quantum dotsCEA, carcinoembryonic antigenCTAB, cetrimonium bromideCTCs, circulating tumor cellsDC, dendritic cellsDLS, dynamic light scatteringEDC, 1-ethyl-3-(3′-dimethylaminopropyl) carbodiimideFBS, fetal bovine serumFluorescence resonance energy transferFRET, fluorescence resonance energy transferGold nanorodsGSH, glutathioneHAuCl4, gold chlorideHelf, human embryonic lung fibroblasts linesHydrogel+IFN-γ+QA, thermal responsive hydrogels co-loaded with AP1-QDsHydrogel+IFN-γ, thermal responsive hydrogels loaded with interferon-γICG, indocyanine greenIFN-γ, interferon-γIR, infraredLAI, liposomes loaded with ICG and encapsulated AuNRsLA, liposomes encapsulated AuNRsLA+NIR, liposomes encapsulated AuNRs with near-infrared irradiationLLC, murine lung cancer cellsLung metastasisMTT, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromideNaBH4, sodium borohydrideNaHTe, sodium hydrogen tellurideNHS, N-hydroxysuccinimideNIR, near-infrared irradiationPD1, programmed cell death protein 1PDL1, programmed cell death-ligand 1PhototherapyPI, propidium iodidePLGA-PEG-PLGA, thermal responsive hydrogelPost-surgical tumor recurrencePTT, photothermal therapyQDs, quantum dotsSynergistic immunotherapyTEM, transmission electron microscopeTheranostics

Identifiers

PMID34386332
PMCPMC8343192
OpenAlexW3151199787

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.