Evidence map›Paper›PMID 34386320›Full record

ReviewActa pharmaceutica Sinica. B2021

Recent advances in nanomedicines for the treatment of ischemic stroke.

Chao Li, Tao Sun, Chen Jiang

Open access · diamondAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Acta pharmaceutica Sinica. B, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 92 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
92citing papers in PubMed, 2 pooled it
5.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

92 citing papers in PubMed, 2 syntheses or guidelines pooled it, 188 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Article
  5. Article
  6. Observational
  7. Review
  8. Article
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  11. Review
  12. Article
  13. Article
  14. Current neuropharmacology · 2026
    Article
  15. Article
  16. Review
  17. Article
  18. Lipid and polymeric nanocarriers for siRNA delivery to the brain.Journal of controlled release : official journal of the Controlled Release Society · 2025
    Review
  19. Review
  20. Article

32 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Chao LiKey Laboratory of Smart Drug Delivery, Ministry of Education, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Department of Pharmaceutics, School of Pharmacy, Research Center on Aging and Medicine, Fudan University, Shanghai 201203, China.
Tao SunKey Laboratory of Smart Drug Delivery, Ministry of Education, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Department of Pharmaceutics, School of Pharmacy, Research Center on Aging and Medicine, Fudan University, Shanghai 201203, China.
Chen JiangKey Laboratory of Smart Drug Delivery, Ministry of Education, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Department of Pharmaceutics, School of Pharmacy, Research Center on Aging and Medicine, Fudan University, Shanghai 201203, China.
Fudan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ischemic stroke is a cerebrovascular disease normally caused by interrupted blood supply to the brain. Ischemia would initiate the cascade reaction consisted of multiple biochemical events in the damaged areas of the brain, where the ischemic cascade eventually leads to cell death and brain infarction. Extensive researches focusing on different stages of the cascade reaction have been conducted with the aim of curing ischemic stroke. However, traditional treatment methods based on antithrombotic therapy and neuroprotective therapy are greatly limited for their poor safety and treatment efficacy. Nanomedicine provides new possibilities for treating stroke as they could improve the pharmacokinetic behavior of drugs

Indexed as

AEPO, asialo-erythropoietinAPOE, apolipoprotein EBBB, blood‒brain barrierBCECs, brain capillary endothelial cellsBlood‒brain barrierCAT, catalaseCe-NPs, ceria nanoparticlesCOX-1, cyclooxygenase-1cRGD, cyclic Arg-Gly-AspCsA, cyclosporine ACXCR-4, C-X-C chemokine receptor type 4DAMPs, damage-associated molecular patternse-PAM-R, arginine-poly-amidoamine esterGFs, growth factorsGPIIb/IIIa, glycoprotein IIb/IIIaHb, hemoglobinHMGB1, high mobility group protein B1ICAM-1, intercellular adhesion molecule-1IL-1β, interleukin-1βIL-6, interleukin-6iNOS, inducible nitric oxide synthaseIschemic cascadeLFA-1, lymphocyte function-associated antigen-1LHb, liposomal HbMCAO, middle cerebral artery occlusionmiRNAs, microRNAsMMPs, matrix metalloproteinasesMSC, mesenchymal stem cellNanomedicineNeuroprotectantNF-κB, nuclear factor-κBNGF, nerve growth factorNMDAR, N-methyl-d-aspartate receptornNOS, neuron nitric oxide synthaseNOS, nitric oxide synthaseNPs, nanoparticlesNSCs, neural stem cellsPBCA, poly-butylcyanoacrylatePCMS, poly (chloromethylstyrene)PEG-PLA, poly (ethylene-glycol)-b-poly (lactide)PEG, poly-ethylene-glycolPLGA NPs, poly (l-lactide-co-glycolide) nanoparticlesPSD-95, postsynaptic density protein-95PSGL-1, P-selectin glycoprotein ligand-1RBCs, red blood cellsReperfusionRES, reticuloendothelial systemRGD, Arg-Gly-AspROS, reactive oxygen speciesSDF-1, stromal cell-derived factor-1SHp, stroke homing peptidesiRNA, small interfering RNASOD, superoxide dismutaseStrokeSUR1-TRPM4, sulfonylurea receptor 1-transient receptor potential melastatin-4TEMPO, 2,2,6,6-tetramethylpiperidine-1-oxylThrombolyticsTIA, transient ischemic attackTNF-α, tumor necrosis factor-α

Identifiers

PMID34386320
PMCPMC8343119
OpenAlexW3106714715

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.