Evidence map›Paper›PMID 34386316›Full record

ReviewActa pharmaceutica Sinica. B2021

3D organoids derived from the small intestine: An emerging tool for drug transport research.

Yuanjin Zhang, Shengbo Huang, Weiguo Zhong, Wenxia Chen, Bingyi Yao, Xin Wang

Open access · diamondAbstract readReview
In one paragraph

Review in Acta pharmaceutica Sinica. B, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.3field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 34 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Review
  6. Mouse Small Intestinal Organoid Cultures.Methods in molecular biology (Clifton, N.J.) · 2025
    Article
  7. Organoids in breast cancer translational research: intersection of technologies.Translational breast cancer research : a journal focusing on translational research in breast cancer · 2025
    Review
  8. Journal of microbiology and biotechnology · 2024
    Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Review
  15. Article
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Yuanjin ZhangChangning Maternity and Infant Health Hospital, East China Normal University, Shanghai 200051, China.
Shengbo HuangChangning Maternity and Infant Health Hospital, East China Normal University, Shanghai 200051, China.
Weiguo ZhongChangning Maternity and Infant Health Hospital, East China Normal University, Shanghai 200051, China.
Wenxia ChenChangning Maternity and Infant Health Hospital, East China Normal University, Shanghai 200051, China.
Bingyi YaoChangning Maternity and Infant Health Hospital, East China Normal University, Shanghai 200051, China.
Xin WangChangning Maternity and Infant Health Hospital, East China Normal University, Shanghai 200051, China.
Shanghai Changning Maternity and Infant Health Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Small intestine

Indexed as

3D organoidASCs, adult somatic stem cellsBCRP, breast cancer resistance proteinBMP, bone morphogenetic proteinCaco-2 cell monolayerCDF, 5(6)-carboxy-2′,7′-dichlorofluoresceincMOAT, canalicular multispecific organic anion transporterDDI, drug–drug interactionsDrug transporterEGF, epidermal growth factorER, efflux ratioESCs, embryonic stem cellsFGF, fibroblast growth factoriPSCs, induced pluripotent stem cellsLgr5+, leucine-rich-repeat-containing G-protein-coupled receptor 5 positiveMCT, monocarboxylate transporter proteinMRP2, multidrug resistance protein 2NBD, nucleotide-binding domainOATP, organic anion transporting polypeptideOCTN, carnitine/organic cation transporterOCT, organic cation transporterPapp, apparent permeability coefficientPEPT, peptide transporter proteinP-glycoproteinP-gp, P-glycoproteinPMAT, plasma membrane monoamine transporterPSCs, pluripotent stem cellsRh123, rhodamine 123SLC, solute carrierSmall intestineTEER, transepithelial electrical resistanceTMDs, transmembrane domains

Identifiers

PMID34386316
PMCPMC8343122
OpenAlexW3112639489

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.