Evidence map›Paper›PMID 34386299›Full record

ArticlePeerJ2021

Inter-ethnic genetic variations and novel variant identification in the partial sequences of

Sagheer Ahmed, Hizbullah Khan, Asifullah Khan, Muhammad Hanif Bangash, Abrar Hussain, Mughal Qayum, Mohammad Hamid Hamdard

Open access · goldAbstract read
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In one paragraph

Article in PeerJ, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.3field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 6 institutions in 2 countries.

Sagheer AhmedDepartment of Basic Medical Sciences, Shifa College of Pharmaceutical Sciences, Shifa Tameer-e-Millat University, Islamabad, Pakistan.ORCID 0000-0003-1560-7588
Hizbullah KhanDepartment of Basic Medical Sciences, Shifa College of Pharmaceutical Sciences, Shifa Tameer-e-Millat University, Islamabad, Pakistan.
Asifullah KhanDepartment of Biochemistry, Abdul Wali Khan University, Mardan, Pakistan.
Muhammad Hanif BangashPakistan Institute of Nuclear Science & Technology, Islamabad, Pakistan.
Abrar HussainBaluchistan University of Information Technology and Management Sciences, Quetta, Pakistan.
Mughal QayumDepartment of Pharmacy, Kohat University of Science & Technology, Kohat, Pakistan.
Mohammad Hamid HamdardFaculty of Biology, Kabul University, Kabul, Afghanistan.
Shifa Tameer-e-Millat University · PKAbdul Wali Khan University Mardan · PKBalochistan University of Information Technology, Engineering and Management Sciences · PKKabul University · AFKohat University of Science and Technology · PKPakistan Institute of Nuclear Science and Technology · PK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSome single nucleotide polymorphisms (SNPs) in the cytochrome P450

methodsArlequin v3.5.DnaSPv6.12. and network 5 resources were used to analyze population genetic variance in the partial

resultsThe data analyses revealed that genetic variance among samples mainly came from differentiation within the ethnic groups. However, significant genetic variation was also found among the various ethnic groups. The high pairwise Fst genetic distinction was observed between Seraiki and Sindhi ethnic groups (Fst = 0.13392,

conclusionThese results may have significant implications in Pakistani ethnicities in the context of drugs metabolized by CYP2B6, especially in Seraiki and Balochi ethnicity. The novel heterogeneous SNP, found in the present study, might lead to altered drug-metabolizing potential of

Indexed as

BalochiCYP2B6PakistanPathanPharmacogeneticsPopulation geneticsPunjabiSeraikiSindhiUrdu

Identifiers

PMID34386299
PMCPMC8312491
OpenAlexW3186344639

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.