Evidence map›Paper›PMID 34386265›Full record

ArticleRegenerative biomaterials2021

Carboxylated-xyloglucan and peptide amphiphile co-assembly in wound healing.

Alessia Ajovalasit, Carlos Redondo-Gómez, Maria Antonietta Sabatino, Babatunde O Okesola, Kristin Braun, Alvaro Mata, Clelia Dispenza

Abstract read
In one paragraph

Article in Regenerative biomaterials, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. Review
  3. A WR3-NHMaterials today. Bio · 2026
    Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Review
  13. Recent advances in regenerative biomaterials.Regenerative biomaterials · 2022
    Review
  14. Self-Assembling Peptides: From Design to Biomedical Applications.International journal of molecular sciences · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Alessia AjovalasitDipartimento di Ingegneria (DI), Università degli Studi di Palermo, Viale delle Scienze, Edificio 6, Palermo 90128, Italy.
Carlos Redondo-GómezSchool of Engineering & Materials Science, Queen Mary University of London, London E1 4NS, UK.
Maria Antonietta SabatinoDipartimento di Ingegneria (DI), Università degli Studi di Palermo, Viale delle Scienze, Edificio 6, Palermo 90128, Italy.
Babatunde O OkesolaSchool of Engineering & Materials Science, Queen Mary University of London, London E1 4NS, UK.
Kristin BraunBlizard Institute, Barts and The London School of Medicine and Dentistry, The Blizard Building, 4 Newark Street, London E1 2AT, UK.
Alvaro MataSchool of Pharmacy, University of Nottingham, Nottingham NG7 2RD, UK.
Clelia DispenzaDipartimento di Ingegneria (DI), Università degli Studi di Palermo, Viale delle Scienze, Edificio 6, Palermo 90128, Italy.ORCID https://orcid.org/0000-0003-0076-5161

Funding

Medical Research Council MR/R015651/1
6 · The paper itself

Abstract

Hydrogel wound dressings can play critical roles in wound healing protecting the wound from trauma or contamination and providing an ideal environment to support the growth of endogenous cells and promote wound closure. This work presents a self-assembling hydrogel dressing that can assist the wound repair process mimicking the hierarchical structure of skin extracellular matrix. To this aim, the co-assembly behaviour of a carboxylated variant of xyloglucan (CXG) with a peptide amphiphile (PA-H3) has been investigated to generate hierarchical constructs with tuneable molecular composition, structure, and properties. Transmission electron microscopy and circular dichroism at a low concentration shows that CXG and PA-H3 co-assemble into nanofibres by hydrophobic and electrostatic interactions and further aggregate into nanofibre bundles and networks. At a higher concentration, CXG and PA-H3 yield hydrogels that have been characterized for their morphology by scanning electron microscopy and for the mechanical properties by small-amplitude oscillatory shear rheological measurements and compression tests at different CXG/PA-H3 ratios. A preliminary biological evaluation has been carried out both

Indexed as

hydrogelpeptide nanofiberself-assemblyskin tissue engineeringwound healing

Identifiers

PMID34386265
PMCPMC8355605

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.