Evidence map›Paper›PMID 34386216›Full record

Trial reportJournal of global health2021

Topical emollient therapy with sunflower seed oil alters the skin microbiota of young children with severe acute malnutrition in Bangladesh: A randomised, controlled study.

Natalie Fischer, Gary L Darmstadt, K M Shahunja, Jonathan M Crowther, Lindsay Kendall, Rachel A Gibson, Tahmeed Ahmed, David A Relman

2 registry-linked trialsOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of global health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.2field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02616289 nacompletednot on this map

Topical Emollient Therapy in the Management of Severe Acute Malnutrition: A Randomized Controlled Clinical Trial in Bangladesh

TypeinterventionalSponsorInternational Centre for Diarrhoeal Disease Research, BangladeshRan2016 to 2019Enrolled212ConditionsChild Malnutrition, Malnutrition in Children, MalnutritionArmsTopical emollient (Sun Flower seed oil)
NCT05461404 naunknown statusnot on this mapstarted 2023, after this paper: background citation

Emollient Therapy for Improved Survival and Growth of Very Low Birth Weight Infants in Zimbabwe

TypeinterventionalSponsorStanford UniversityRan2023 to 2025Enrolled520ConditionsVery Low Birth Weight InfantArmsTopical Emollient Therapy
3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 3 countries.

Natalie FischerDivision of Infectious Diseases & Geographic Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, California, USA.
Gary L DarmstadtPrematurity Research Center, Department of Pediatrics, Stanford University School of Medicine, Stanford, California, USA.
K M ShahunjaNutrition and Clinical Services Division, International Centre for Diarroheal Disease Research Bangladesh (icddr,b), Dhaka, Bangladesh.
Jonathan M CrowtherJMC Scientific Consulting Ltd, Egham, Surrey, UK.
Lindsay KendallGlaxoSmithKline R&D, Global Health Catalyst, Stevenage, UK.
Rachel A GibsonGlaxoSmithKline R&D, Global Health Catalyst, Stevenage, UK.
Tahmeed AhmedNutrition and Clinical Services Division, International Centre for Diarroheal Disease Research Bangladesh (icddr,b), Dhaka, Bangladesh.
David A RelmanDivision of Infectious Diseases & Geographic Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, California, USA.
Stanford University · USGlaxoSmithKline (United Kingdom) · GBFood and Nutrition Service · USInternational Centre for Diarrhoeal Disease Research · BD

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTopical emollient therapy with sunflower seed oil (SSO) reduces risk of sepsis and mortality in very preterm infants in low- or middle-income countries (LMICs). Proposed mechanisms include modulation of skin and possibly gut barrier function. The skin and gut microbiota play important roles in regulating barrier function, but the effects of emollient therapy on these microbiotas are poorly understood.

methodsWe characterised microbiota structure and diversity with 16S rRNA gene amplicon sequence data and ecological statistics in 20 children with severe acute malnutrition (SAM) aged 2-24 months, at four skin sites and in stool, during a randomised, controlled trial of emollient therapy with SSO in Bangladesh. Microbes associated with therapy were identified with tree-based sparse discriminant analysis.

resultsThe skin microbiota of Bangladeshi children with SAM was highly diverse and displayed significant variation in structure as a function of physical distance between sites. Microbiota structure differed between the study groups (

conclusionsEmollient therapy altered the skin microbiota in a consistent and temporally coherent manner. We speculate that therapy with SSO enhances skin barrier function in part through alterations in the microbiota, and through systemic mechanisms. Strategies to strengthen skin and gut barrier function in populations at risk, such as children in LMICs like Bangladesh, might include deliberate manipulation of their skin microbiota.

trial registrationClinicalTrials.gov: NCT02616289.

Indexed as

MicrobiotaSevere Acute MalnutritionBangladeshChildChild, PreschoolEmollientsHumansInfantInfant, NewbornInfant, PrematureRNA, Ribosomal, 16SSunflower OilEmollientsRNA, Ribosomal, 16SSunflower Oil

Identifiers

PMID34386216
PMCPMC8325932
OpenAlexW3191509369

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.