Evidence map›Paper›PMID 34385994›Full record

ReviewFrontiers in microbiology2021

Mesenchymal Stromal Cell-Derived Tailored Exosomes Treat Bacteria-Associated Diabetes Foot Ulcers: A Customized Approach From Bench to Bed.

Alok Raghav, Prashant Tripathi, Brijesh Kumar Mishra, Goo-Bo Jeong, Shahid Banday, Kirti Amresh Gautam, Qazi Noorul Mateen, Prem Singh, Manish Singh, Akhil Singla and 1 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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  13. Research progress on the mechanism of exosome-mediated virus infection.Frontiers in cellular and infection microbiology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Alok RaghavMultidisciplinary Research Unit, Department of Health Research, MoHFW, GSVM Medical College, Kanpur, India.
Prashant TripathiDepartment of Biochemistry, GSVM Medical College, Kanpur, India.
Brijesh Kumar MishraDepartment of Endocrinology, UCMS, GTB Hospital, New Delhi, India.
Goo-Bo JeongDepartment of Anatomy and Cell Biology, College of Medicine, Gachon University, Incheon, South Korea.
Shahid BandayDepartment of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School, Worcester, MA, United States.
Kirti Amresh GautamMultidisciplinary Research Unit, Department of Health Research, MoHFW, GSVM Medical College, Kanpur, India.
Qazi Noorul MateenDepartment of Biochemical Engineering, Indian Institute of Technology Delhi, New Delhi, India.
Prem SinghDepartment of Medicine, GSVM Medical College, Kanpur, India.
Manish SinghDepartment of Neurosurgery, GSVM Medical College, Kanpur, India.
Akhil SinglaDepartment of Medicine, Maharishi Markandeshwar College and Hospital, Maharishi Markandeshwar University, Solan, India.
Jamal AhmadFaculty of Medicine, Rajiv Gandhi Centre for Diabetes and Endocrinology, JN Medical College, Aligarh Muslim University, Aligarh, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Exosomes are nano-vesicles of endosomal origin inherited with characteristics of drug delivery and cargo loading. Exosomes offer a diverse range of opportunities that can be exploited in the treatment of various diseases post-functionalization. This membrane engineering is recently being used in the management of bacteria-associated diabetic foot ulcers (DFUs). Diabetes mellitus (DM) is among the most crippling disease of society with a large share of its imposing economic burden. DM in a chronic state is associated with the development of micro- and macrovascular complications. DFU is among the diabetic microvascular complications with the consequent occurrence of diabetic peripheral neuropathy. Mesenchymal stromal cell (MSC)-derived exosomes post-tailoring hold promise to accelerate the diabetic wound repair in DFU associated with bacterial inhabitant. These exosomes promote the antibacterial properties with regenerative activity by loading bioactive molecules like growth factors, nucleic acids, and proteins, and non-bioactive substances like antibiotics. Functionalization of MSC-derived exosomes is mediated by various physical, chemical, and biological processes that effectively load the desired cargo into the exosomes for targeted delivery at specific bacterial DFUs and wound. The present study focused on the application of the cargo-loaded exosomes in the treatment of DFU and also emphasizes the different approaches for loading the desired cargo/drug inside exosomes. However, more studies and clinical trials are needed in the domain to explore this membrane engineering.

Indexed as

bacterial infectioncustomized exosomesdiabetes foot ulcersdiabetes mellitusexosomes

Identifiers

PMID34385994
PMCPMC8354005

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.