Evidence map›Paper›PMID 34385977›Full record

ArticleFrontiers in endocrinology2021

Age Influences the Prognosis of Anaplastic Thyroid Cancer Patients.

Na Kong, Qiqi Xu, Ziqin Zhang, Aimin Cui, Shen Tan, Nan Bai

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Article in Frontiers in endocrinology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Na KongGeneral Surgery of Beijing Jishuitan Hospital, The Fourth Clinical Medical College of Peking University, Beijing, China.
Qiqi XuGeneral Surgery of Beijing Jishuitan Hospital, The Fourth Clinical Medical College of Peking University, Beijing, China.
Ziqin ZhangGeneral Surgery of Beijing Jishuitan Hospital, The Fourth Clinical Medical College of Peking University, Beijing, China.
Aimin CuiGeneral Surgery of Beijing Jishuitan Hospital, The Fourth Clinical Medical College of Peking University, Beijing, China.
Shen TanGeneral Surgery of Beijing Jishuitan Hospital, The Fourth Clinical Medical College of Peking University, Beijing, China.
Nan BaiGeneral Surgery of Beijing Jishuitan Hospital, The Fourth Clinical Medical College of Peking University, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The staging system for patients with anaplastic thyroid cancer (ATC) was updated in the 8 Methods: The clinical information on ATC patients was acquired from the Surveillance, Epidemiology, and End Results Program public database. Youden's index and X-tile analyses were used to calculate the high-point age at diagnosis associated with prognosis. Cox proportional hazards models, Kaplan-Meier curves, and 1000-person-year were then used for verifying the accuracy of the high-point age. Results: After inclusion/exclusion criteria was applied, 586 patients were included in this study. The high-point age was determined to be 70 years by both the Youden's index and X-tile plot methods. The hazard ratio was 1.662 (95% confidence interval [CI]: 1.321-2.092), indicating that there was an increased risk of poor prognosis for patients > 70 years of age. The cancer-specific mortality rates per 1000-person-years for patients ≤ and > 70 years-old were 949.980 (95% CI: 827.323-1090.822) and 1546.667 (95% CI: 1333.114-1794.428), respectively. P-values were < 0.001 for the results shown above. Conclusion: Our study found that age influenced the prognosis of ATC patients. Furthermore, we determined that the high-point age at diagnosis was 70 years and that > 70 years of age was associated with a poor prognosis. These results provide a useful addition to the staging manual and can improve the diagnosis, treatment strategies and prognosis of ATC patients.

Indexed as

AdultAgedAged, 80 and overAge FactorsFemaleFollow-Up StudiesHumansMaleMiddle AgedPrognosisSurvival RateThyroid Carcinoma, AnaplasticThyroidectomyThyroid Neoplasmsage at diagnosisAJCCanaplastic thyroid cancerSEERstaging system

Identifiers

PMID34385977
PMCPMC8353231

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.