Evidence map›Paper›PMID 34385910›Full record

ArticleFrontiers in neuroanatomy2021

Capicua Regulates Dendritic Morphogenesis Through Ets in Hippocampal Neurons

Keqin Li, Shuai Shao, Tongjie Ji, Min Liu, Lufeng Wang, Ying Pang, Mu Chen, Siyi Xu, Kuiming Zhang, Qi Wang and 9 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neuroanatomy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 3 institutions in 1 country.

Keqin LiDepartment of Neurosurgery, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.
Shuai ShaoDepartment of Neurosurgery, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Tongjie JiDepartment of Neurosurgery, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.
Min LiuDepartment of Neurosurgery, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.
Lufeng WangDepartment of Neurology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.
Ying PangDepartment of Neurosurgery, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.
Mu ChenDepartment of Neurosurgery, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.
Siyi XuDepartment of Neurosurgery, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.
Kuiming ZhangDepartment of Neurosurgery, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.
Qi WangDepartment of Neurosurgery, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.
Zhongwei ZhuangDepartment of Neurosurgery, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.
Liang WeiDepartment of Neurosurgery, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.
Yanfei ZhangDepartment of Neurosurgery, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.
Yanlin ChenDepartment of Neurosurgery, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Yang WangDepartment of Emergency, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Jing ZhangDepartment of Neurosurgery, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.
Kui ChenDepartment of Neurosurgery, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.
Hao LianDepartment of Neurosurgery, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.
Chunlong ZhongDepartment of Neurosurgery, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.
Shanghai East Hospital · CNShanghai Jiao Tong University · CNXinHua Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Capicua (Cic), a transcriptional repressor frequently mutated in brain cancer oligodendroglioma, is highly expressed in adult neurons. However, its function in the dendritic growth of neurons in the hippocampus remains poorly understood. Here, we confirmed that Cic was expressed in hippocampal neurons during the main period of dendritogenesis, suggesting that Cic has a function in dendrite growth. Loss-of-function and gain-of function assays indicated that Cic plays a central role in the inhibition of dendritic morphogenesis and dendritic spines

Indexed as

capicuadendritic growthEts factorsspine growthtranscriptional repressor

Identifiers

PMID34385910
PMCPMC8353115
OpenAlexW3184922212

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.