Evidence map›Paper›PMID 34385712›Full record

ArticleNature immunology2021

TCF-1 controls T

Abu Osman, Bingyu Yan, Ying Li, Kevin D Pavelko, Jasmine Quandt, Abdulrahman Saadalla, Mahendra Pal Singh, Majid Kazemian, Fotini Gounari, Khashayarsha Khazaie

Open access · greenAbstract read
In one paragraph

Article in Nature immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.

0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed
4.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

56 citing papers in PubMed, 79 citations in OpenAlex.

  1. Article
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  9. CD38 endows local antigen-specific TNature immunology · 2026
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Abu Osman *Department of Immunology, Mayo Clinic, Rochester, MN, USA.ORCID http://orcid.org/0000-0003-3232-2007
Bingyu Yan *Department of Biochemistry, Purdue University, Purdue, IN, USA.ORCID http://orcid.org/0000-0003-4429-8200
Ying LiDivision of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN, USA.
Kevin D PavelkoDepartment of Immunology, Mayo Clinic, Rochester, MN, USA.ORCID http://orcid.org/0000-0001-7555-1315
Jasmine QuandtDepartment of Medicine, Section of Rheumatology, University of Chicago, Chicago, IL, USA.
Abdulrahman SaadallaDepartment of Immunology, Mayo Clinic, Rochester, MN, USA.
Mahendra Pal SinghDepartment of Immunology, Mayo Clinic, Rochester, MN, USA.
Majid KazemianDepartment of Biochemistry, Purdue University, Purdue, IN, USA. kazemian@purdue.edu.ORCID http://orcid.org/0000-0001-7080-8820
Fotini GounariDepartment of Medicine, Section of Rheumatology, University of Chicago, Chicago, IL, USA. fgounari@uchicago.edu.ORCID http://orcid.org/0000-0003-2936-066X
Khashayarsha KhazaieDepartment of Immunology, Mayo Clinic, Rochester, MN, USA. Khazaie@mayo.edu.ORCID http://orcid.org/0000-0002-7884-1817
Mayo Clinic · USUniversity of Chicago · USPurdue University West Lafayette · US

Funding

ULTRASTRUCTURE AND CYTOMORPHOLOGY COREP30DK042086 · NIDDK · UNIVERSITY OF CHICAGO · PI CHANG, EUGENE B · 1990 to 2025
$29.8M
How beta-catenin expands Foxp3+RORgammat+ Pro-inflammatoryT-regulatory cells - RenewalR01AI108682 · NIAID · UNIVERSITY OF CHICAGO · PI GOUNARI, FOTINI, KHAZAIE, KHASHAYARSHA · 2014 to 2024
$5.1M
Epigenetic mechanisms of carcinogenesis by Parvimonas micra, an oral cavity commensal turned colon cancer pathogenR01CA264048 · NCI · MAYO CLINIC ARIZONA · PI BOARDMAN, LISA ALLYN, GOUNARI, FOTINI · 2021 to 2025
$3.1M
Molecular functions of Tcf-1 in DP thymocytesR01AI147652 · NIAID · UNIVERSITY OF CHICAGO · PI GOUNARI, FOTINI · 2020 to 2024
$2.0M
Joint submission for administrative supplement proposal: HIPAA aligned storage and computing solutionR35GM138283 · NIGMS · PURDUE UNIVERSITY · PI KAZEMIAN, MAJID · 2020 to 2024
$2.0M
NCI NIH HHS R01 CA264048NIAID NIH HHS R01 AI108682NIAID NIH HHS R01 AI147652NIDDK NIH HHS P30 DK042086NIGMS NIH HHS R35 GM138283
6 · The paper itself

Abstract

The transcription factor TCF-1 is essential for the development and function of regulatory T (T

Indexed as

Adenomatous Polyposis ColiAnimalsCell ProliferationColonic NeoplasmsForkhead Transcription FactorsGene Expression RegulationHepatocyte Nuclear Factor 1-alphaImmunologic MemoryInflammationMembrane ProteinsMiceMice, KnockoutTh17 CellsT-Lymphocytes, CytotoxicT-Lymphocytes, RegulatoryTranscription, Geneticerythroid differentiation regulator 1, mouseForkhead Transcription FactorsFoxp3 protein, mouseHepatocyte Nuclear Factor 1-alphaHnf1a protein, mouseMembrane ProteinsTumor Suppressor Proteins

Identifiers

PMID34385712
PMCPMC8428683
OpenAlexW3193140392

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.