ArticleEuropean journal of human genetics : EJHG2022
Routinization of prenatal screening with the non-invasive prenatal test: pregnant women's perspectives.
Article in European journal of human genetics : EJHG, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- Exploring measurement tools used to assess knowledge, attitudes, and perceptions of pregnant women toward prenatal screening: A systematic review.Women's health (London, England)Pooled it
- Does an educational video for aneuploidy screening improve informed choice among pregnant women? A randomised controlled trial.Prenatal diagnosis · 2023Trial
- Navigating uncertainty during non-invasive prenatal testing: Genetic counselors' experiences of supporting autonomous reproductive decision-making.Journal of genetic counseling · 2026Article
- Development of a Tailored Online Video-Based Assistant to Support Prenatal Screening Decisions in Couples With Limited Health Literacy: User-Centered Design Approach.JMIR formative research · 2026Article
- Midwives 'views of parents' questions and expectations on prenatal genetic testing - identifying informational needs in prenatal genetic counselling.Journal of community genetics · 2025Article
- Age-specific uptake of non-invasive prenatal tests (NIPT) in Germany: a decision theory-based analysis.Journal of community genetics · 2025Article
- Rethinking the Burden of Traditional Informed Consent Prior to Prenatal Genetic Screening.The Hastings Center report · 2025Article
- Attitudes About NIPT Routinisation: A Report from a Qualitative Study of 20 UK Healthcare Professionals.Health care analysis : HCA : journal of health philosophy and policy · 2025Article
- Article
- Karyotyping with amniotic fluid in 6,572 pregnant women and pregnancy outcomes--A single-center retrospective study.PloS one · 2025Article
- NIPT Integration as a Patient-Paid Prenatal Screening Option-Observations and Challenges from a Bulgarian Genetic Counseling Center.Medical sciences (Basel, Switzerland) · 2024Article
- Mainstreaming genetics into Italian prenatal care: exploring the future implementation of non-invasive prenatal testing (NIPT) in the Italian National Healthcare System using stakeholder interviews.BMJ public health · 2024Article
- Women's preferences for NIPT as a first-line test in England and France: Challenges for genetic counseling practices.Journal of genetic counseling · 2024Article
- Factors influencing pregnant women's decision to accept or decline prenatal screening and diagnosis - a qualitative study.Journal of community genetics · 2024Article
- Effectiveness of Video Assisted Teaching Programme on Level of Knowledge and Attitude Regarding Prenatal Genetic Testing among Antenatal Mother.Journal of pharmacy & bioallied sciences · 2024Article
- Psychological impact of additional findings detected by genome-wide Non-Invasive Prenatal Testing (NIPT): TRIDENT-2 study.European journal of human genetics : EJHG · 2024Article
- Advancements of non-invasive prenatal testing: the role of obstetricians.Frontiers in medicine · 2024Review
- Non-invasive prenatal testing (NIPT): is routinization problematic?BMC medical ethics · 2023Article
- Informed choice and routinization of the second-trimester anomaly scan: a national cohort study in the Netherlands.BMC pregnancy and childbirth · 2023Article
- Experiences of pregnant women with genome-wide non-invasive prenatal testing in a national screening program.European journal of human genetics : EJHG · 2023Article
Corrections and comments
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Authors and funding
13 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Due to the favorable test characteristics of the non-invasive prenatal test (NIPT) in the screening of fetal aneuploidy, there has been a strong and growing demand for implementation. In the Netherlands, NIPT is offered within a governmentally supported screening program as a first-tier screening test for all pregnant women (TRIDENT-2 study). However, concerns have been raised that the test's favorable characteristics might lead to uncritical use, also referred to as routinization. This study addresses women's perspectives on prenatal screening with NIPT by evaluating three aspects related to routinization: informed choice, freedom to choose and (personal and societal) perspectives on Down syndrome. Nationwide, a questionnaire was completed by 751 pregnant women after receiving counseling for prenatal screening. Of the respondents, the majority (75.5%) made an informed choice for prenatal screening as measured by the multidimensional measure of informed choice (MMIC). Education level and religious affiliation were significant predictors of informed choice. The main reason to accept screening was "seeking reassurance" (25.5%), and the main reason to decline was "every child is welcome" (30.6%). The majority of respondents (87.7%) did not perceive societal pressure to test. Differences between test-acceptors and test-decliners in personal and societal perspectives on Down syndrome were found. Our study revealed high rates of informed decision-making and perceived freedom to choose regarding fetal aneuploidy screening, suggesting that there is little reason for concern about routinization of NIPT based on the perspectives of Dutch pregnant women. Our findings highlight the importance of responsible implementation of NIPT within a national screening program.
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