ArticleNature ecology & evolution2021
Dog colour patterns explained by modular promoters of ancient canid origin.
Article in Nature ecology & evolution, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 56 citations in OpenAlex.
- Beyond Appearances: The Hidden Coat Diversity of the Sicilian Mastiff Revealed by Integrated Phenotypic and Genetic Analyses.Veterinary sciences · 2026Article
- Image feature embedding with a deep learning framework improves genome-wide association studies on dog endophenotypes.Science advances · 2026Article
- Beyond Mendel: a call to revisit the genotype-phenotype map through new experimental paradigms.Genetics · 2026Article
- Genetic testing predicts appearance but not behavior in dogs.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Dogs of War: The Effect of War-Inflicted Environmental Damage on Free-Ranging Domestic Dogs.Evolutionary applications · 2025Article
- Determinants of de novo mutations in extended pedigrees of 43 dog breeds.Genome biology · 2025Article
- Exome analysis reveals species divergence in TYR and identifies species genetic markers in five endemic Macaca species on Sulawesi Island.BMC ecology and evolution · 2025Article
- Taurine pangenome uncovers a segmental duplication upstream ofGenome research · 2025Article
- Article
- The DoGA consortium expression atlas of promoters and genes in 100 canine tissues.Nature communications · 2024Article
- Comparative Population Genomics of Arctic Sled Dogs Reveals a Deep and Complex History.Genome biology and evolution · 2024Article
- A sequence of SVA retrotransposon insertions in ASIP shaped human pigmentation.Nature genetics · 2024Article
- Exploring the Maintaining Period and the Differentially Expressed Genes between the Yellow and Black Stripes of the Juvenile Stripe in the Offspring of Wild Boar and Duroc.Animals : an open access journal from MDPI · 2024Article
- Coat colour in marsupials: genetic variants at theRoyal Society open science · 2024Article
- Ancestry dynamics and trait selection in a designer cat breed.Current biology : CB · 2024Article
- Pedigree-Based Genetic Diversity in the South African Boerboel Dog Breed.Animals : an open access journal from MDPI · 2024Article
- Exploring the Domestication Syndrome Hypothesis in Dogs: Pigmentation Does Not Predict Cortisol Levels.Animals : an open access journal from MDPI · 2023Article
- Genome sequencing of 2000 canids by the Dog10K consortium advances the understanding of demography, genome function and architecture.Genome biology · 2023Article
- A Chinese indicine pangenome reveals a wealth of novel structural variants introgressed from otherGenome research · 2023Article
- The Shepherd and the Hunter: A Genomic Comparison of Italian Dog Breeds.Animals : an open access journal from MDPI · 2023Article
Corrections and comments
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Authors and funding
17 authors at 7 institutions in 5 countries.
Funding
Abstract
Distinctive colour patterns in dogs are an integral component of canine diversity. Colour pattern differences are thought to have arisen from mutation and artificial selection during and after domestication from wolves but important gaps remain in understanding how these patterns evolved and are genetically controlled. In other mammals, variation at the ASIP gene controls both the temporal and spatial distribution of yellow and black pigments. Here, we identify independent regulatory modules for ventral and hair cycle ASIP expression, and we characterize their action and evolutionary origin. Structural variants define multiple alleles for each regulatory module and are combined in different ways to explain five distinctive dog colour patterns. Phylogenetic analysis reveals that the haplotype combination for one of these patterns is shared with Arctic white wolves and that its hair cycle-specific module probably originated from an extinct canid that diverged from grey wolves more than 2 million years ago. Natural selection for a lighter coat during the Pleistocene provided the genetic framework for widespread colour variation in dogs and wolves.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.