Evidence map›Paper›PMID 34385602›Full record

ArticleMolecular psychiatry2021

Impaired spike-gamma coupling of area CA3 fast-spiking interneurons as the earliest functional impairment in the App

Luis Enrique Arroyo-García, Arturo G Isla, Yuniesky Andrade-Talavera, Hugo Balleza-Tapia, Raúl Loera-Valencia, Laura Alvarez-Jimenez, Giusy Pizzirusso, Simone Tambaro, Per Nilsson, André Fisahn

Open access · hybridAbstract read
In one paragraph

Article in Molecular psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
5.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 75 citations in OpenAlex.

  1. Article
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  3. Decoding the mechanisms of amyloid-β in synaptic toxicity.Journal of Alzheimer's disease : JAD · 2026
    Review
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  6. Excitation-inhibition homeostasis in Alzheimer's disease: a selective multiscale review of mechanisms, sex differences, and therapeutic opportunities.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Review
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  17. GABATranslational psychiatry · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 2 countries.

Luis Enrique Arroyo-GarcíaNeuronal Oscillations Laboratory; Division of Neurogeriatrics; Center for Alzheimer Research; Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Solna, Sweden. luis.enrique.arroyogarcia@ki.se.ORCID http://orcid.org/0000-0002-9206-0179
Arturo G IslaNeuronal Oscillations Laboratory; Division of Neurogeriatrics; Center for Alzheimer Research; Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Solna, Sweden.ORCID http://orcid.org/0000-0002-8176-3522
Yuniesky Andrade-TalaveraNeuronal Oscillations Laboratory; Division of Neurogeriatrics; Center for Alzheimer Research; Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Solna, Sweden.ORCID http://orcid.org/0000-0002-5295-0169
Hugo Balleza-TapiaNeuronal Oscillations Laboratory; Division of Neurogeriatrics; Center for Alzheimer Research; Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Solna, Sweden.
Raúl Loera-ValenciaDivision of Neurogeriatrics; Center for Alzheimer Research; Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Solna, Sweden.ORCID http://orcid.org/0000-0001-9376-0049
Laura Alvarez-JimenezDivision of Neurogeriatrics; Center for Alzheimer Research; Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Solna, Sweden.ORCID http://orcid.org/0000-0003-4286-8230
Giusy PizzirussoNeuronal Oscillations Laboratory; Division of Neurogeriatrics; Center for Alzheimer Research; Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Solna, Sweden.
Simone TambaroDivision of Neurogeriatrics; Center for Alzheimer Research; Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Solna, Sweden.
Per NilssonDivision of Neurogeriatrics; Center for Alzheimer Research; Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Solna, Sweden.ORCID http://orcid.org/0000-0001-6450-0870
André FisahnNeuronal Oscillations Laboratory; Division of Neurogeriatrics; Center for Alzheimer Research; Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Solna, Sweden. andre.fisahn@ki.se.ORCID http://orcid.org/0000-0003-1480-175X
Karolinska Institutet · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In Alzheimer's disease (AD) the accumulation of amyloid-β (Aβ) correlates with degradation of cognition-relevant gamma oscillations. The gamma rhythm relies on proper neuronal spike-gamma coupling, specifically of fast-spiking interneurons (FSN). Here we tested the hypothesis that decrease in gamma power and FSN synchrony precede amyloid plaque deposition and cognitive impairment in App

Indexed as

Alzheimer DiseaseMobile ApplicationsAmyloid beta-PeptidesAmyloid beta-Protein PrecursorAnimalsDisease Models, AnimalGene Knock-In TechniquesInterneuronsMiceMice, Inbred C57BLMice, TransgenicAmyloid beta-PeptidesAmyloid beta-Protein Precursor

Identifiers

PMID34385602
PMCPMC8758494
OpenAlexW3188291986

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.