ArticleMolecular psychiatry2021
Disrupted intrinsic functional brain topology in patients with major depressive disorder.
Open access · hybridAbstract readMulticenter Study
In one paragraph
Article in Molecular psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 132 papers, 1 of them a synthesis that pooled it.
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132citing papers in PubMed, 1 pooled it
20.5field-weighted citation impact, top 1% of its field
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Who cites it
132 citing papers in PubMed, 1 synthesis or guideline pooled it, 236 citations in OpenAlex.
- Resting-state network alterations in depression: a comprehensive meta-analysis of functional connectivity.Psychological medicine · 2025Pooled it
- Aerobic Exercise and Subthreshold Depressive Symptoms in Adolescents: Secondary Analysis of a Randomized Clinical Trial.JAMA network open · 2026Trial
- Brain functional network correlates and predictors of the perioperative antidepressant effect of esketamine in breast cancer patients: a double-blind randomized controlled trial using resting-state fMRI and graph theory.Translational psychiatry · 2026Trial
- Effects of computerized cognitive training on functional brain networks in patients with vascular cognitive impairment and no dementia.CNS neuroscience & therapeutics · 2024Trial
- Electroconvulsive therapy shifting brain dynamics toward more adaptive and integrated states in treatment-resistant depression based on a hidden markov model.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026Article
- Depression: higher temporal variability of the functional connectivity of the ventromedial prefrontal cortex and hippocampal system.NeuroImage. Clinical · 2026Article
- Age-related degradation of cerebellar functional network topology.GeroScience · 2026Article
- Resting-state fMRI-based machine learning for predicting SSRI treatment response in major depressive disorder.BMC psychiatry · 2026Article
- Cholinergic Modulation of Proteinoid Microsphere Networks as Prebiotic Depression Models.ACS physical chemistry Au · 2026Article
- Unraveling the Individualized Shared and Distinct Dynamic Functional Connectivity in Idiopathic Autism Spectrum Disorder and Fragile X Syndrome.CNS neuroscience & therapeutics · 2026Article
- Topological Alterations of Functional Brain Networks in Post-Stroke Cognitive Impairment: a Graph-Theoretical Study.Clinical neuroradiology · 2026Article
- Cell-type and spatiotemporal transcriptional signatures of white matter morphometric similarity network alterations in major depressive disorder.Psychological medicine · 2026Article
- Treatment-related topological reorganization of the structural connectome in major depressive disorder with suicidal ideation.BMC psychiatry · 2026Article
- Alpha-band fronto-limbic hyperconnectivity in adolescents with major depression and suicidal ideation.BMC psychiatry · 2026Article
- Graph theory reveals functional connectome disruptions in adolescent major depressive disorder with childhood trauma.Communications medicine · 2026Article
- Increased Aperiodic Exponents Track Depression Symptom Severity.bioRxiv : the preprint server for biology · 2026Article
- Disrupted brain network dynamics and cognitive dysfunction in drug-naive major depressive disorder: an EEG microstate study.European archives of psychiatry and clinical neuroscience · 2026Article
- Neural vulnerability to stress in adolescents: a longitudinal study using polyconnectomic scoring of depression risk.BMC medicine · 2026Article
- Comparing local brain activity and distant functional connectivity in transgender women compared to cisgender controls.Scientific reports · 2026Article
- The hidden costs of screen time: altered brain network efficiency in children with autism spectrum disorder.BMC psychiatry · 2026Article
72 more citing papers are in PubMed but not listed here.
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Authors and funding
73 authors at 20 institutions in 2 countries.
Hong Yang *Department of Radiology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
Xiao Chen *CAS Key Laboratory of Behavioral Science, Institute of Psychology, Chinese Academy of Sciences, Beijing, China.
Zuo-Bing Chen *Department of Rehabilitation Medicine, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
Le LiCenter for Cognitive Science of Language, Beijing Language and Culture University, Beijing, China.
Xue-Ying LiCAS Key Laboratory of Behavioral Science, Institute of Psychology, Chinese Academy of Sciences, Beijing, China.
Francisco Xavier CastellanosDepartment of Child and Adolescent Psychiatry, NYU Grossman School of Medicine, New York, NY, USA.
Tong-Jian BaiAnhui Medical University, Hefei, Anhui, China.
Qi-Jing BoBeijing Anding Hospital, Capital Medical University, Beijing, China.
Jun CaoDepartment of Psychiatry, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Zhi-Kai ChangCAS Key Laboratory of Behavioral Science, Institute of Psychology, Chinese Academy of Sciences, Beijing, China.
Guan-Mao ChenThe First Affiliated Hospital of Jinan University, Guangzhou, Guangdong, China.
Ning-Xuan ChenCAS Key Laboratory of Behavioral Science, Institute of Psychology, Chinese Academy of Sciences, Beijing, China.
Wei ChenDepartment of Psychiatry, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Chang ChengThe Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
Yu-Qi ChengFirst Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.
Xi-Long CuiThe Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
Jia DuanDepartment of Psychiatry, First Affiliated Hospital, China Medical University, Shenyang, Liaoning, China.
Yiru FangShanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID http://orcid.org/0000-0002-8748-9085
Qi-Yong GongHuaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, Sichuan, China.ORCID http://orcid.org/0000-0002-5912-4871
Wen-Bin GuoThe Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
Zheng-Hua HouDepartment of Psychosomatics and Psychiatry, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu, China.
Lan HuDepartment of Psychiatry, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Li KuangDepartment of Psychiatry, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Feng LiBeijing Anding Hospital, Capital Medical University, Beijing, China.
Hui-Xian LiCAS Key Laboratory of Behavioral Science, Institute of Psychology, Chinese Academy of Sciences, Beijing, China.
Kai-Ming LiHuaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, Sichuan, China.
Tao LiAffiliated Mental Health Center & Hangzhou Seventh People's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Yan-Song LiuDepartment of Clinical Psychology, Suzhou Psychiatric Hospital, The Affiliated Guangji Hospital of Soochow University, Suzhou, Jiangsu, China.
Zhe-Ning LiuThe Institute of Mental Health, Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
Yi-Cheng LongThe Institute of Mental Health, Second Xiangya Hospital of Central South University, Changsha, Hunan, China.ORCID http://orcid.org/0000-0003-4231-2136
Bin LuCAS Key Laboratory of Behavioral Science, Institute of Psychology, Chinese Academy of Sciences, Beijing, China.
Qing-Hua LuoDepartment of Psychiatry, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Hua-Qing MengDepartment of Psychiatry, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Daihui PengShanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Hai-Tang QiuDepartment of Psychiatry, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Jiang QiuFaculty of Psychology, Southwest University, Chongqing, China.
Yue-Di ShenDepartment of Diagnostics, Affiliated Hospital, Hangzhou Normal University Medical School, Hangzhou, Zhejiang, China.
Yu-Shu ShiDepartment of Radiology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
Tian-Mei SiNational Clinical Research Center for Mental Disorders (Peking University Sixth Hospital) & Key Laboratory of Mental Health, Ministry of Health (Peking University), Beijing, China.
Yan-Qing TangDepartment of Psychiatry, First Affiliated Hospital, China Medical University, Shenyang, Liaoning, China.
Chuan-Yue WangBeijing Anding Hospital, Capital Medical University, Beijing, China.ORCID http://orcid.org/0000-0001-6549-3713
Fei WangDepartment of Psychiatry, First Affiliated Hospital, China Medical University, Shenyang, Liaoning, China.
Kai WangAnhui Medical University, Hefei, Anhui, China.
Li WangNational Clinical Research Center for Mental Disorders (Peking University Sixth Hospital) & Key Laboratory of Mental Health, Ministry of Health (Peking University), Beijing, China.
Xiang WangThe Second Xiangya Hospital of Central South University, Changsha, Hunan, China.ORCID http://orcid.org/0000-0001-9258-2017
Ying WangThe First Affiliated Hospital of Jinan University, Guangzhou, Guangdong, China.ORCID http://orcid.org/0000-0002-0388-4177
Yu-Wei WangCAS Key Laboratory of Behavioral Science, Institute of Psychology, Chinese Academy of Sciences, Beijing, China.
Xiao-Ping WuXi'an Central Hospital, Xi'an, Shaanxi, China.
Xin-Ran WuFaculty of Psychology, Southwest University, Chongqing, China.
Chun-Ming XieDepartment of Neurology, Affiliated ZhongDa Hospital of Southeast University, Nanjing, Jiangsu, China.ORCID http://orcid.org/0000-0002-5978-9689
Guang-Rong XieThe Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
Hai-Yan XieDepartment of Psychiatry, The Fourth Affiliated Hospital, College of Medicine, Zhejiang University, Yiwu, Zhejiang, China.
Peng XieInstitute of Neuroscience, Chongqing Medical University, Chongqing, China.ORCID http://orcid.org/0000-0002-0081-6048
Xiu-Feng XuFirst Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.
Jian YangChongqing Key Laboratory of Neurobiology, Chongqing, China.
Jia-Shu YaoDepartment of Psychiatry, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Shu-Qiao YaoThe Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
Ying-Ying YinDepartment of Psychosomatics and Psychiatry, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu, China.
Yong-Gui YuanDepartment of Psychosomatics and Psychiatry, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu, China.
Yu-Feng ZangCenter for Cognition and Brain Disorders, Institutes of Psychological Sciences, Hangzhou Normal University, Hangzhou, Zhejiang, China.
Ai-Xia ZhangFirst Hospital of Shanxi Medical University, Taiyuan, Shanxi, China.
Hong ZhangXi'an Central Hospital, Xi'an, Shaanxi, China.
Ke-Rang ZhangFirst Hospital of Shanxi Medical University, Taiyuan, Shanxi, China.
Lei ZhangLaboratory of Psychological Health and Imaging, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Zhi-Jun ZhangDepartment of Neurology, Affiliated ZhongDa Hospital of Southeast University, Nanjing, Jiangsu, China.ORCID http://orcid.org/0000-0001-5480-0888
Jing-Ping ZhaoThe Institute of Mental Health, Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
Rubai ZhouShanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yi-Ting ZhouMental Health Center and Psychiatric Laboratory, West China Hospital of Sichuan University, Chengdu, Sichuan, China.
Jun-Juan ZhuDepartment of Psychiatry, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Zhi-Chen ZhuCAS Key Laboratory of Behavioral Science, Institute of Psychology, Chinese Academy of Sciences, Beijing, China.
Chao-Jie ZouFirst Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.
Xi-Nian ZuoState Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, China.ORCID http://orcid.org/0000-0001-9110-585X
Chao-Gan YanCAS Key Laboratory of Behavioral Science, Institute of Psychology, Chinese Academy of Sciences, Beijing, China. ycg.yan@gmail.com.ORCID http://orcid.org/0000-0003-3413-5977
Central South University · CNInstitute of Psychology, Chinese Academy of Sciences · CNThe Affiliated Yongchuan Hospital of Chongqing Medical University · CNShanghai Jiao Tong University · CNZhongda Hospital Southeast University · CNZhejiang University · CNCapital Medical University · CNChina Medical University · CNKunming Medical University · CNSichuan University · CNSouthwest University · CNAnhui Medical University · CNPeking University · CNShanxi Medical University · CNSir Run Run Shaw Hospital · CNAffiliated Hospital of Hangzhou Normal University · CNBeijing Language and Culture University · CNBeijing Normal University · CNChildren's Hospital of Chongqing Medical University · CNChinese Academy of Medical Sciences & Peking Union Medical College · CN
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aberrant topological organization of whole-brain networks has been inconsistently reported in studies of patients with major depressive disorder (MDD), reflecting limited sample sizes. To address this issue, we utilized a big data sample of MDD patients from the REST-meta-MDD Project, including 821 MDD patients and 765 normal controls (NCs) from 16 sites. Using the Dosenbach 160 node atlas, we examined whole-brain functional networks and extracted topological features (e.g., global and local efficiency, nodal efficiency, and degree) using graph theory-based methods. Linear mixed-effect models were used for group comparisons to control for site variability; robustness of results was confirmed (e.g., multiple topological parameters, different node definitions, and several head motion control strategies were applied). We found decreased global and local efficiency in patients with MDD compared to NCs. At the nodal level, patients with MDD were characterized by decreased nodal degrees in the somatomotor network (SMN), dorsal attention network (DAN) and visual network (VN) and decreased nodal efficiency in the default mode network (DMN), SMN, DAN, and VN. These topological differences were mostly driven by recurrent MDD patients, rather than first-episode drug naive (FEDN) patients with MDD. In this highly powered multisite study, we observed disrupted topological architecture of functional brain networks in MDD, suggesting both locally and globally decreased efficiency in brain networks.
Indexed as
Major Depressive DisorderBrainBrain MappingHumansMagnetic Resonance ImagingNeural PathwaysSample Size
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