Evidence map›Paper›PMID 34385519›Full record

ArticleScientific reports2021

Oral health and all-cause, cardiovascular disease, and respiratory mortality in older people in the UK and USA.

Eftychia Kotronia, Heather Brown, A Olia Papacosta, Lucy T Lennon, Robert J Weyant, Peter H Whincup, S Goya Wannamethee, Sheena E Ramsay

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

58 citing papers in PubMed, 4 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Eftychia KotroniaPopulation Health Sciences Institute, Newcastle University, The Baddiley-Clark Building, Richardson Road, Newcastle upon Tyne, NE2 4AX, UK. e.kotronia2@newcastle.ac.uk.
Heather BrownPopulation Health Sciences Institute, Newcastle University, The Baddiley-Clark Building, Richardson Road, Newcastle upon Tyne, NE2 4AX, UK.
A Olia PapacostaDepartment of Primary Care and Population Health, Institute of Epidemiology and Health Care, University College London, London, UK.
Lucy T LennonDepartment of Primary Care and Population Health, Institute of Epidemiology and Health Care, University College London, London, UK.
Robert J WeyantDepartment of Dental Public Health, School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Peter H WhincupPopulation Health Research Institute, St George's University of London, London, UK.
S Goya WannametheeDepartment of Primary Care and Population Health, Institute of Epidemiology and Health Care, University College London, London, UK.
Sheena E RamsayPopulation Health Sciences Institute, Newcastle University, The Baddiley-Clark Building, Richardson Road, Newcastle upon Tyne, NE2 4AX, UK.

Funding

Peripheral Nerve Function Decline in an Aged CohortR01AG028050 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI STROTMEYER, ELSA S. · 2007 to 2015
$3.5M
End of Life in the Very OldR01NR012459 · NINR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ALBERT, STEVEN M, LUNNEY, JUNE R · 2011 to 2015
$2.7M
Understanding the contribution of poor oral health to sarcopenia in older age and underlying mechanisms using UK and US cohort studiesR03DE028505 · NIDCR · UNIVERSITY OF NEWCASTLE · PI RAMSAY, SHEENA ESTHER · 2019 to 2020
$213k
British Heart Foundation RG/08/013/25942British Heart Foundation RG/13/16/30528British Heart Foundation RG/19/4/34452Department of HealthMedical Research Council G0501859Medical Research Council G1002391Medical Research Council MR/K02325X/1NIA NIH HHS R01 AG028050NIDCR NIH HHS R03 DE028505NINR NIH HHS R01 NR012459
6 · The paper itself

Abstract

Preventing deterioration of oral health in older age can be crucial for survival. We aimed to examine associations of oral health problems with all-cause, cardiovascular disease (CVD), and respiratory mortality in older people. We used cohort data from the British Regional Health Study (BRHS) (N = 2147, 71-92 years), and the Health, Aging and Body Composition (HABC) Study (USA) (N = 3075, 71-80 years). Follow-up was 9 years (BRHS) and 15 years (HABC Study). Oral health comprised tooth loss, periodontal disease, dry mouth, and self-rated oral health. Cox regression was performed for all-cause mortality, competing risks for CVD mortality, and accelerated failure time models for respiratory mortality. In the BRHS, tooth loss was associated with all-cause mortality (hazard ratio (HR) = 1.59, 95% CI 1.09, 2.31). In the HABC Study, tooth loss, dry mouth, and having ≥ 3 oral problems were associated with all-cause mortality; periodontal disease was associated with increased CVD mortality (subdistribution hazard ratio (SHR) = 1.49, 95% CI 1.01, 2.20); tooth loss, and accumulation of oral problems were associated with high respiratory mortality (tooth loss, time ratio (TR) = 0.73, 95% CI 0.54, 0.98). Findings suggest that poor oral health is associated with mortality. Results highlight the importance of improving oral health to lengthen survival in older age.

Indexed as

Oral HealthAdultAgedAged, 80 and overCardiovascular DiseasesCause of DeathFemaleHumansMaleProportional Hazards ModelsRespiratory Tract DiseasesUnited KingdomUnited States

Identifiers

PMID34385519
PMCPMC8361186

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.