ArticleNPJ schizophrenia2021
Impaired cerebro-cerebellar white matter connectivity and its associations with cognitive function in patients with schizophrenia.
Article in NPJ schizophrenia, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 38 citations in OpenAlex.
- Cognitive impairment and associated white matter organization abnormalities across the illness course of schizophrenia.European archives of psychiatry and clinical neuroscience · 2026Article
- Cerebellar Tracts Microstructural Characteristics and Severity of Language Impairment in Post-stroke Patients with Aphasia: A DTI Study.Cerebellum (London, England) · 2026Article
- High-Resolution Diffusion Tensor Imaging of the Cerebellum and Brainstem in Chiari Malformation Type I: Association with Function and Pain.Cerebellum (London, England) · 2026Article
- Associations between cerebellum and major psychiatric disorders: a bidirectional Mendelian randomization study.European archives of psychiatry and clinical neuroscience · 2026Article
- Temporal recalibration in schizophrenia: a compensatory timing trap?Neuroscience of consciousness · 2026Article
- Altered System-Level Integration Between Working Memory and Gaze Dynamics in Children Treated for Posterior Fossa Tumors.Psychology in Russia : state of the art · 2026Article
- Involvement of the Cerebellar Peduncles inInternational journal of molecular sciences · 2025Review
- Transcriptional Regulators in the Cerebellum in Chronic Schizophrenia: Novel Possible Targets for Pharmacological Interventions.International journal of molecular sciences · 2025Article
- Consistent cerebellar pathway-cognition associations across pre-adolescents & young adults: a diffusion MRI study of 9000+ participants.bioRxiv : the preprint server for biology · 2025Article
- Evaluation of vascular cognitive impairment and identification of imaging markers using machine learning: a multimodal MRI study.Frontiers in neurology · 2025Article
- Striatal Functional Hypoconnectivity in Patients With Schizophrenia Suffering From Negative Symptoms, Longitudinal Findings.Schizophrenia bulletin · 2024Article
- Structural and functional connectivity in relation to executive functions in antipsychotic-naïve patients with first episode schizophrenia and levels of glutamatergic metabolites.Schizophrenia (Heidelberg, Germany) · 2024Article
- Deep multimodal saliency parcellation of cerebellar pathways: Linking microstructure and individual function through explainable multitask learning.Human brain mapping · 2024Article
- Pons-to-Cerebellum Hypoconnectivity Along the Psychosis Spectrum and Associations With Sensory Prediction and Hallucinations in Schizophrenia.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2024Article
- Cerebro-cerebellar gray matter abnormalities associated with cognitive impairment in patients with recent-onset and chronic schizophrenia.Schizophrenia (Heidelberg, Germany) · 2024Article
- A statistical method for image-mediated association studies discovers genes and pathways associated with four brain disorders.American journal of human genetics · 2024Article
- New clues for the role of cerebellum in schizophrenia and the associated cognitive impairment.Frontiers in cellular neuroscience · 2024Review
- Aberrant cortico-thalamo-cerebellar network interactions and their association with impaired cognitive functioning in patients with schizophrenia.Schizophrenia (Heidelberg, Germany) · 2023Article
- Investigating brain aging trajectory deviations in different brain regions of individuals with schizophrenia using multimodal magnetic resonance imaging and brain-age prediction: a multicenter study.Translational psychiatry · 2023Article
- A Comprehensive Analysis of Cerebellar Volumes in the 22q11.2 Deletion Syndrome.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2023Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Schizophrenia is a complex brain disorder of unknown etiology. Based on the notion of "cognitive dysmetria," we aimed to investigate aberrations in structural white matter (WM) connectivity that links the cerebellum to cognitive dysfunction in patients with schizophrenia. A total of 112 participants (65 patients with schizophrenia and 47 healthy controls [HCs]) were enrolled and underwent diffusion tensor imaging. Between-group voxel-wise comparisons of cerebellar WM regions (superior/middle [MCP]/inferior cerebellar peduncle and pontine crossing fibers) were performed using Tract-Based Spatial Statistics. Cognitive function was assessed using the Trail Making Test Part A/B (TMT-A/B), Wisconsin Card Sorting Test (WCST), and Rey-Kim Memory Test in 46 participants with schizophrenia. WM connectivity, measured as fractional anisotropy (FA), was significantly lower in the MCP in participants with schizophrenia than in HCs. The mean FAs extracted from the significant MCP cluster were inversely correlated with poorer cognitive performance, particularly longer time to complete the TMB-B (r = 0.559, p < 0.001) and more total errors in the WCST (r = 0.442, p = 0.003). Our findings suggest that aberrant cerebro-cerebellar communication due to disrupted WM connectivity may contribute to cognitive impairments, a core characteristic of schizophrenia. Our results may expand our understanding of the neurobiology of schizophrenia based on the cerebro-cerebellar interconnectivity of the brain.
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Registered trials
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