ArticleNature communications2021
Heritability and interindividual variability of regional structure-function coupling.
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 109 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
109 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Genetic and phylogenetic uncoupling of structure and function in human transmodal cortex.Nature communications · 2022Pooled it
- Analysis of correlation between structural changes and functional response in post-stroke motor recovery after cM1 LF-rTMS: an exploratory randomized trial.Scientific reports · 2026Trial
- Brain structural and functional connectivity converge prenatally but diverge after birth.PLoS biology · 2026Article
- Hierarchical structural-functional coupling reorganization after acute sleep deprivation: Links to spatial working memory and lateralization.Cognitive, affective & behavioral neuroscience · 2026Article
- Structural-functional network decoupling in early stage amyotrophic lateral sclerosis reveals cell-type specific transcriptional signatures.BMC medicine · 2026Article
- Mapping Whole-Brain Nonlinear Structure-Function Dynamics in Aging via Neural Granger Causality.Brain topography · 2026Article
- DTI-ALPS and subcortical structural-functional coupling mediate the impact of sleep quality on working memory in insomnia disorder.Psychological medicine · 2026Article
- Variations of structural-functional coupling in post-traumatic stress disorder are associated with underlying molecular and transcriptional features.Psychological medicine · 2026Article
- Structure-function dynamics in healthy cognitive aging: a graph signal processing approach.Brain structure & function · 2026Article
- Developmental changes of the white matter functional connectome.Molecular psychiatry · 2026Article
- Opportunities and pitfalls of data contextualization in neuroimaging.Nature reviews. Neuroscience · 2026Review
- Structural Connectivity of Functionally Defined Episodic Memory Networks: A Large-Scale Connectome-Behavior Study.Brain and behavior · 2026Article
- The microstructure-weighted human connectome: network properties and structure-function correlations across spatial scales.bioRxiv : the preprint server for biology · 2026Article
- Tract-explainable and underexplained synchrony play complementary roles in the functional organization of the brain.bioRxiv : the preprint server for biology · 2026Article
- Article
- Longitudinal Multimodal Neuroimaging After Traumatic Brain Injury.Human brain mapping · 2026Article
- Structuro-Functional Differentiation and Coupling of Gyri and Sulci in the Neonatal Cortex.Human brain mapping · 2026Article
- Decoupling of neurophysiological activity from structure mirrors global microarchitectural and neuromodulatory trends.Communications biology · 2026Article
- Structural-functional connectivity coupling in motor-brain networks following acute ischemic stroke.Journal of neuroengineering and rehabilitation · 2026Article
- Structure-function coupling in the human brainstem.bioRxiv : the preprint server for biology · 2026Article
49 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
White matter structural connections are likely to support flow of functional activation or functional connectivity. While the relationship between structural and functional connectivity profiles, here called SC-FC coupling, has been studied on a whole-brain, global level, few studies have investigated this relationship at a regional scale. Here we quantify regional SC-FC coupling in healthy young adults using diffusion-weighted MRI and resting-state functional MRI data from the Human Connectome Project and study how SC-FC coupling may be heritable and varies between individuals. We show that regional SC-FC coupling strength varies widely across brain regions, but was strongest in highly structurally connected visual and subcortical areas. We also show interindividual regional differences based on age, sex and composite cognitive scores, and that SC-FC coupling was highly heritable within certain networks. These results suggest regional structure-function coupling is an idiosyncratic feature of brain organisation that may be influenced by genetic factors.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.