ArticleNPJ biofilms and microbiomes2021
Alternating magnetic fields and antibiotics eradicate biofilm on metal in a synergistic fashion.
Article in NPJ biofilms and microbiomes, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 37 citations in OpenAlex.
- Magnetic induction heating: where will the field go next?Chemical Society reviews · 2026Review
- Electrolytic cleaning as a biofilm control strategy on medical implants: mechanisms, evidence and translational perspectives.Frontiers in microbiology · 2026Review
- Alternating magnetic fields enhance anti-biofilm activity across pathogen and antibiotic space.Scientific reports · 2025Article
- Periprosthetic joint infection after arthroplasty: advances and future prospects.Journal of orthopaedic surgery and research · 2025Review
- Alternating Magnetic Fields Remove Biofilms but Damage Cells on Implant Models Also with Negligible Bulk Heating.ACS applied materials & interfaces · 2025Article
- Antimicrobial resistance in orthopedics: microbial insights, clinical impact, and the necessity of a multidisciplinary approach-a review.Acta orthopaedica · 2025Review
- Induction heating combined with antibiotics or SAAP-148 effectively reduces biofilm-embedded Staphylococcus aureus on a fracture-related implant mimic.Bone & joint research · 2025Article
- Microbiome modulation of implant-related infection by a novel miniaturized pulsed electromagnetic field device.NPJ biofilms and microbiomes · 2025Article
- Iron-Oxide Nanoparticles Embedded in 3D-Printed PLA/HA Scaffolds for Magnetic Hyperthermia Therapy: An Experimental-Numerical Analysis of Thermal Behavior.Materials (Basel, Switzerland) · 2024Article
- Study of the effect of magnetic fields on static degradation of Fe and Fe-12Mn-1.2C in balanced salts modified Hanks' solution.Bioactive materials · 2024Article
- Evaluation of treatment of methicillin-resistantAntimicrobial agents and chemotherapy · 2024Article
- Antibiotic Augmentation of Thermal Eradication ofPathogens (Basel, Switzerland) · 2024Article
- Evaluation of Treatment of Methicillin-ResistantbioRxiv : the preprint server for biology · 2024Article
- Intermittent alternating magnetic fields diminish metal-associated biofilm in vivo.Scientific reports · 2023Article
- Using SMART Magnetic Fluids and Gels for Prevention and Destruction of Bacterial Biofilms.Microorganisms · 2023Article
- Application of survival analysis to model proliferation likelihood ofFrontiers in bioengineering and biotechnology · 2023Article
- Effectiveness of mechanical cleaning, antibiotics, and induction heating on eradication ofBone & joint research · 2022Article
- Current treatments for biofilm-associated periprosthetic joint infection and new potential strategies.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2022Review
- Applications of Antimicrobial Photodynamic Therapy against Bacterial Biofilms.International journal of molecular sciences · 2022Review
- Microwaves, a potential treatment for bacteria: A review.Frontiers in microbiology · 2022Review
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
Hundreds of thousands of human implant procedures require surgical revision each year due to infection. Infections are difficult to treat with conventional antibiotics due to the formation of biofilm on the implant surface. We have developed a noninvasive method to eliminate biofilm on metal implants using heat generated by intermittent alternating magnetic fields (iAMF). Here, we demonstrate that heat and antibiotics are synergistic in biofilm elimination. For Pseudomonas aeruginosa biofilm, bacterial burden was reduced >3 log with iAMF and ciprofloxacin after 24 h compared with either treatment alone (p < 0.0001). This effect was not limited by pathogen or antibiotic as similar biofilm reductions were seen with iAMF and either linezolid or ceftriaxone in Staphylococcus aureus. iAMF and antibiotic efficacy was seen across various iAMF settings, including different iAMF target temperatures, dose durations, and dosing intervals. Initial mechanistic studies revealed membrane disruption as one factor important for AMF enhanced antibacterial activity in the biofilm setting. This study demonstrates the potential of utilizing a noninvasive approach to reduce biofilm off of metallic implants.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.