Evidence map›Paper›PMID 34385418›Full record

ArticleTranslational psychiatry2021

N-methyl-D-aspartate receptor availability in first-episode psychosis: a PET-MR brain imaging study.

Katherine Beck, Atheeshaan Arumuham, Mattia Veronese, Barbara Santangelo, Colm J McGinnity, Joel Dunn, Robert A McCutcheon, Stephen J Kaar, Nisha Singh, Toby Pillinger and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Translational psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  15. Hippocampal circuit dysfunction in psychosis.Translational psychiatry · 2022
    Review
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Katherine BeckDepartment of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, Kings College London, De Crespigny Park, London, SE5 8AF, UK. katherine.beck@kcl.ac.uk.ORCID http://orcid.org/0000-0003-2769-8237
Atheeshaan ArumuhamDepartment of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, Kings College London, De Crespigny Park, London, SE5 8AF, UK.
Mattia VeroneseDepartment of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, Kings College London, De Crespigny Park, London, SE5 8AF, UK.ORCID http://orcid.org/0000-0003-3562-0683
Barbara SantangeloDepartment of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, Kings College London, De Crespigny Park, London, SE5 8AF, UK.
Colm J McGinnityKing's College London & Guy's and St Thomas' PET Centre, School of Biomedical Engineering & Imaging Sciences, King's College London, St Thomas' Hospital, London, SE1 7EH, UK.
Joel DunnKing's College London & Guy's and St Thomas' PET Centre, School of Biomedical Engineering & Imaging Sciences, King's College London, St Thomas' Hospital, London, SE1 7EH, UK.ORCID http://orcid.org/0000-0002-0936-9993
Robert A McCutcheonDepartment of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, Kings College London, De Crespigny Park, London, SE5 8AF, UK.ORCID http://orcid.org/0000-0003-1102-2566
Stephen J KaarDepartment of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, Kings College London, De Crespigny Park, London, SE5 8AF, UK.
Nisha SinghCentre for Neuroimaging Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Toby PillingerDepartment of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, Kings College London, De Crespigny Park, London, SE5 8AF, UK.ORCID http://orcid.org/0000-0002-6074-2626
Faith BorganDepartment of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, Kings College London, De Crespigny Park, London, SE5 8AF, UK.ORCID http://orcid.org/0000-0002-5017-5226
James StoneDepartment of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, Kings College London, De Crespigny Park, London, SE5 8AF, UK.ORCID http://orcid.org/0000-0003-3051-0135
Sameer JauharDepartment of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, Kings College London, De Crespigny Park, London, SE5 8AF, UK.ORCID http://orcid.org/0000-0002-3878-3659
Teresa SementaKing's College London & Guy's and St Thomas' PET Centre, School of Biomedical Engineering & Imaging Sciences, King's College London, St Thomas' Hospital, London, SE1 7EH, UK.
Federico TurkheimerCentre for Neuroimaging Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.ORCID http://orcid.org/0000-0002-3766-3815
Alexander HammersKing's College London & Guy's and St Thomas' PET Centre, School of Biomedical Engineering & Imaging Sciences, King's College London, St Thomas' Hospital, London, SE1 7EH, UK.
Oliver D HowesDepartment of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, Kings College London, De Crespigny Park, London, SE5 8AF, UK. oliver.howes@kcl.ac.uk.

Funding

Department of HealthMedical Research Council MC_U120097115Medical Research Council MR/K022733/1Medical Research Council MR/N013042/1Medical Research Council MR/N027078/1Wellcome TrustWellcome Trust 094849/Z/10/ZWellcome Trust 215747/Z/19/ZWellcome Trust MR/N013042/1Wellcome Trust WT 203148/Z/16/Z
6 · The paper itself

Abstract

N-methyl-D-aspartate receptor (NMDAR) hypofunction is hypothesised to underlie psychosis but this has not been tested early in illness. To address this, we studied 40 volunteers (21 patients with first-episode psychosis and 19 matched healthy controls) using PET imaging with an NMDAR selective ligand, [

Indexed as

Psychotic DisordersSchizophreniaBrainHumansNeuroimagingPositron-Emission TomographyReceptors, N-Methyl-D-AspartateReceptors, N-Methyl-D-Aspartate

Identifiers

PMID34385418
PMCPMC8361127

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.