ArticleScience (New York, N.Y.)2021
High-fat diet-induced colonocyte dysfunction escalates microbiota-derived trimethylamine
Open access · greenAbstract read
In one paragraph
Article in Science (New York, N.Y.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 197 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
197citing papers in PubMed, 2 pooled it
16.8field-weighted citation impact, top 1% of its field
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
197 citing papers in PubMed, 2 syntheses or guidelines pooled it, 296 citations in OpenAlex.
- Effect of Dietary Choline Consumption on the Development of Urinary Urgency Incontinence in a Longitudinal Cohort of Women.International urogynecology journal · 2024Pooled it
- Hotspots and research trends of gut microbiome in polycystic ovary syndrome: a bibliometric analysis (2012-2023).Frontiers in microbiology · 2024Pooled it
- Gut microbiota-regulated glutathione metabolic rhythms restore obesity-induced colonic inflammatory oscillations.Gut microbes · 2026Article
- Targeting the gut-bone axis in osteoporosis: probiotic interventions and other microbiota-based therapeutic strategies.Gut microbes · 2026Review
- Article
- Gut microbiota metabolic reprogramming drives the development of metabolic diseases in the host.Gut microbes · 2026Review
- Host metabolism shapes the intestinal microbiota: a top-down paradigm of environmental selection pressure.Gut microbes · 2026Review
- Review
- Impact of infrared moxibustion for patients with mild hyperlipidemia: a protocol for a randomized controlled trial.Annals of medicine · 2026Article
- The intersection of colorectal cancer and cardiovascular disease: shared mechanisms and clinical implications.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026Review
- Microbiome ecology and antibiotic treatment failure: resistance spread, microbial competition and community engineering.Microbial genomics · 2026Review
- Colonic metabolomic and transcriptomic alterations in a mouse model of metabolic syndrome.American journal of physiology. Gastrointestinal and liver physiology · 2026Article
- Microbiota-derived indole limitsScience advances · 2026Article
- Intestinal HIF1α is dispensable for bariatric surgery-mediated metabolic benefits but protects against diet-induced obesity and hepatic steatosis.International journal of obesity (2005) · 2026Article
- Bile acid supplementation in a high-fat diet improved growth performance, lipid deposition, ferroptosis, and intestinal health in Pacific white shrimp (Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2026Article
- Modulating the Gut-Microbiota-Brain Axis in Alzheimer's Disease: Therapeutic Potential of Nutritional and Metabolic Factors.CNS neuroscience & therapeutics · 2026Review
- Thiazolidinedione Use and Risk of Bacterial Enteric Infection Among Adults With Type 2 Diabetes Mellitus.Open forum infectious diseases · 2026Article
- Phylogenize2: robust phylogenetic methods link genes to phenotypes across host-associated and environmental microbiomes.bioRxiv : the preprint server for biology · 2026Article
- Oxygen homeostasis: new insight of gut microbiota-host interactions.NPJ biofilms and microbiomes · 2026Review
- Metabolic Reprogramming-Driven Cardiovascular Immune Damage: From Glyco-Lipotoxicity and Epigenetic Memory to Multidimensional Cross-Organ Communication Networks.International journal of molecular sciences · 2026Review
137 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors at 5 institutions in 2 countries.
Woongjae YooVanderbilt Institute for Infection, Immunology, and Inflammation, Vanderbilt University Medical Center, Nashville, TN 37232, USA.ORCID 0000-0002-4139-8217
Jacob K ZiebaVanderbilt Institute for Infection, Immunology, and Inflammation, Vanderbilt University Medical Center, Nashville, TN 37232, USA.ORCID 0000-0003-4163-6569
Nora J FoegedingDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.ORCID 0000-0002-4197-9249
Teresa P TorresVanderbilt Institute for Infection, Immunology, and Inflammation, Vanderbilt University Medical Center, Nashville, TN 37232, USA.ORCID 0000-0003-2316-4705
Catherine D SheltonVanderbilt Institute for Infection, Immunology, and Inflammation, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Nicolas G ShealyVanderbilt Institute for Infection, Immunology, and Inflammation, Vanderbilt University Medical Center, Nashville, TN 37232, USA.ORCID 0000-0002-1700-7570
Austin J ByndlossDepartment of Medical Microbiology and Immunology, School of Medicine, University of California at Davis, Davis, CA 95616, USA.
Stephanie A CevallosDepartment of Medical Microbiology and Immunology, School of Medicine, University of California at Davis, Davis, CA 95616, USA.ORCID 0000-0002-7091-1577
Erik GertzDepartment of Biological Sciences, California State University, Sacramento, CA 95819, USA.
Connor R TiffanyDepartment of Medical Microbiology and Immunology, School of Medicine, University of California at Davis, Davis, CA 95616, USA.ORCID 0000-0001-8188-7720
Julia D ThomasVanderbilt Institute for Infection, Immunology, and Inflammation, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Yael LitvakDepartment of Nutrition, University of California at Davis, Davis, CA 95616, USA.ORCID 0000-0002-0183-2816
Henry NguyenDepartment of Medical Microbiology and Immunology, School of Medicine, University of California at Davis, Davis, CA 95616, USA.ORCID 0000-0002-6737-1485
Erin E OlsanDepartment of Medical Microbiology and Immunology, School of Medicine, University of California at Davis, Davis, CA 95616, USA.ORCID 0000-0002-5650-1133
Brian J BennettDepartment of Biological Sciences, California State University, Sacramento, CA 95819, USA.ORCID 0000-0002-0766-3195
Jeffrey C RathmellVanderbilt Institute for Infection, Immunology, and Inflammation, Vanderbilt University Medical Center, Nashville, TN 37232, USA.ORCID 0000-0002-4106-3396
Amy S MajorVanderbilt Institute for Infection, Immunology, and Inflammation, Vanderbilt University Medical Center, Nashville, TN 37232, USA.ORCID 0000-0003-0377-2041
Andreas J BäumlerDepartment of Medical Microbiology and Immunology, School of Medicine, University of California at Davis, Davis, CA 95616, USA. mariana.x.byndloss@vumc.org jbaumler@ucdavis.edu.ORCID 0000-0001-9152-7809
Mariana X ByndlossDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA. mariana.x.byndloss@vumc.org jbaumler@ucdavis.edu.ORCID 0000-0002-2122-4156
Vanderbilt University Medical Center · USUniversity of California, Davis · USWestern Human Nutrition Research Center · USCalifornia State University, Sacramento · USHebrew University of Jerusalem · IL
Funding
Translational Analysis CoreP30DK058404 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI RICHARD M. PEEK · 2002 to 2026
$29.9MVanderbilt-Ingram Cancer Center SPORE in Gastrointestinal CancerP50CA236733 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI STEPHEN W. FESIK · 2019 to 2026
$19.6MTRAINING PROGRAM IN ENVIRONMENTAL TOXICOLOGYT32ES007028 · NIEHS · VANDERBILT UNIVERSITY · PI F PETER Guengerich, Fiona Edith Harrison · 1985 to 2026
$15.7MVirulence Factors of SalmonellaR01AI044170 · NIAID · UNIVERSITY OF CALIFORNIA DAVIS · PI BAUMLER, ANDREAS J · 1999 to 2022
$8.5MTRAINING IN GASTROENTEROLOGYT32DK007673 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI RICHARD M. PEEK · 1992 to 2026
$8.4MExacerbation of colitis by the microbiotaR01AI112445 · NIAID · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Andreas J Baumler · 2015 to 2026
$6.2MMicrobiota Outgrowth by SalmonellaR01AI096528 · NIAID · UNIVERSITY OF CALIFORNIA AT DAVIS · PI BAUMLER, ANDREAS J · 2011 to 2025
$6.1MMechanism of Colonization ResistanceR01AI112949 · NIAID · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Andreas J Baumler · 2016 to 2026
$5.2MUC Davis CTSC TL1 Administrative Supplement to Recognize Excellence in Diversity, Equity, Inclusion, and Accessibility MentorshipTL1TR001861 · NCATS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI MEDICI, VALENTINA · 2016 to 2025
$4.7MExploiting metabolic vulnerabilities of CD4 T cell subsets to control inflammatory diseaseR01DK105550 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Jeffrey C Rathmell · 2015 to 2026
$4.7MChemical Biology of Infectious Diseases (CBID) Training ProgramT32AI112541 · NIAID · VANDERBILT UNIVERSITY · PI Eric P Skaar · 2015 to 2026
$4.0MBiological Mechanisms through which TMAO Promotes AtherosclerosisR01HL148110 · NHLBI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ALLAYEE, HOOMAN, SHIH, DIANA MOUHAN · 2020 to 2023
$2.5MBLRD VA I01 BX005333NCATS NIH HHS TL1 TR001861NCI NIH HHS P50 CA236733NHLBI NIH HHS R01 HL148110NIAID NIH HHS R01 AI044170NIAID NIH HHS R01 AI096528NIAID NIH HHS R01 AI112445NIAID NIH HHS R01 AI112949NIAID NIH HHS R21 AI146432NIAID NIH HHS R21 AI153069NIAID NIH HHS R37 AI044170NIAID NIH HHS R56 AI112949NIAID NIH HHS T32 AI112541NIDDK NIH HHS P30 DK058404NIDDK NIH HHS R01 DK105550NIDDK NIH HHS R01 DK131104NIDDK NIH HHS T32 DK007673NIEHS NIH HHS T32 ES007028
Abstract
A Western-style, high-fat diet promotes cardiovascular disease, in part because it is rich in choline, which is converted to trimethylamine (TMA) by the gut microbiota. However, whether diet-induced changes in intestinal physiology can alter the metabolic capacity of the microbiota remains unknown. Using a mouse model of diet-induced obesity, we show that chronic exposure to a high-fat diet escalates
Indexed as
Diet, High-FatAnimalsCell HypoxiaCholineColonEnergy MetabolismEpithelial CellsEscherichia coliFecesGastrointestinal MicrobiomeInflammationIntestinal MucosaMaleMethylaminesMiceMice, Inbred C57BLCholineMethylaminesNitratestrimethyloxamine
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.