ArticlePediatrics2021
Deaths in Children and Adolescents Associated With COVID-19 and MIS-C in the United States.
Article in Pediatrics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
47 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Association of race, ethnicity, and pediatric long COVID and MIS-C: a systematic review and meta-analysis.BMC infectious diseases · 2026Pooled it
- A Suspected Case of Multisystem Inflammatory Disease in Children Following COVID-19 Vaccination: A Case Report and Systematic Literature Review.The Pediatric infectious disease journal · 2022Pooled it
- Severe Outcomes Associated With SARS-CoV-2 Infection in Children: A Systematic Review and Meta-Analysis.Frontiers in pediatrics · 2022Pooled it
- Article
- Case Report: MIS-C precipitating DKA and renal failure in a morbidly obese male with type 2 diabetes mellitus.Frontiers in pediatrics · 2026Article
- Performance of whole blood interferon-γ release assays in SARS-CoV-2 and tuberculosis is age dependent.Infection · 2025Article
- Epidemic profile of COVID-19 child deaths in Sri Lanka: a retrospective nationwide analysis.BMC pediatrics · 2025Article
- Six clinical phenotypes with prognostic implications were identified by unsupervised machine learning in children and adolescents with SARS-CoV-2 infection: results from a German nationwide registry.Respiratory research · 2024Article
- The Effect of Age and Comorbidities: Children vs. Adults in Their Response to SARS-CoV-2 Infection.Viruses · 2024Article
- Vaccine Mandates: Weighing the Common Good vs Personal Conscience and Autonomy.The Linacre quarterly · 2024Article
- Diagnosis, treatment and prevention of severe acute respiratory syndrome coronavirus 2 infection in children: experts' consensus statement updated for the Omicron variant.World journal of pediatrics : WJP · 2024Article
- The Psychosocial Impact of the COVID-19 Pandemic on Families of Youth of Color: A Prospective Cohort Study.Journal of pediatric psychology · 2024Article
- Article
- Obesity and Outcomes of Kawasaki Disease and COVID-19-Related Multisystem Inflammatory Syndrome in Children.JAMA network open · 2023Article
- Racial and Ethnic Variation in ECMO Utilization and Outcomes in Pediatric Cardiac ICU Patients.JACC. Advances · 2023Article
- COVID-19-related adolescent mortality and morbidity in nineteen European countries.European journal of pediatrics · 2023Article
- SARS-CoV-2 Infection and COVID-19 in Children.Clinics in chest medicine · 2023Review
- Resource use and disease severity of children hospitalized for COVID-19 versus multisystem inflammatory syndrome in children (MIS-C) in Canada.Canada communicable disease report = Releve des maladies transmissibles au Canada · 2023Article
- Covid-19 omicron variant infection in neonates of Guangdong province-a report of 52 cases.Frontiers in pediatrics · 2023Article
- COVID-19 vaccination in children as a global dilemma through an ethical lens: A retrospective review.Health science reports · 2023Article
Corrections and comments
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Authors and funding
46 authors.
Funding
Abstract
objectivesTo describe the demographics, clinical characteristics, and hospital course among persons <21 years of age with a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-associated death.
methodsWe conducted a retrospective case series of suspected SARS-CoV-2-associated deaths in the United States in persons <21 years of age during February 12 to July 31, 2020. All states and territories were invited to participate. We abstracted demographic and clinical data, including laboratory and treatment details, from medical records.
resultsWe included 112 SARS-CoV-2-associated deaths from 25 participating jurisdictions. The median age was 17 years (IQR 8.5-19 years). Most decedents were male (71, 63%), 31 (28%) were Black (non-Hispanic) persons, and 52 (46%) were Hispanic persons. Ninety-six decedents (86%) had at least 1 underlying condition; obesity (42%), asthma (29%), and developmental disorders (22%) were most commonly documented. Among 69 hospitalized decedents, common complications included mechanical ventilation (75%) and acute respiratory failure (82%). The sixteen (14%) decedents who met multisystem inflammatory syndrome in children (MIS-C) criteria were similar in age, sex, and race and/or ethnicity to decedents without MIS-C; 11 of 16 (69%) had at least 1 underlying condition.
conclusionsSARS-CoV-2-associated deaths among persons <21 years of age occurred predominantly among Black (non-Hispanic) and Hispanic persons, male patients, and older adolescents. The most commonly reported underlying conditions were obesity, asthma, and developmental disorders. Decedents with coronavirus disease 2019 were more likely than those with MIS-C to have underlying medical conditions.
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