Evidence map›Paper›PMID 34385340›Full record

ArticleJournal of nuclear medicine : official publication, Society of Nuclear Medicine2022

Initial Clinical Experience with

Justin Ferdinandus, Pedro Fragoso Costa, Lukas Kessler, Manuel Weber, Nader Hirmas, Karina Kostbade, Sebastian Bauer, Martin Schuler, Marit Ahrens, Hans-Ulrich Schildhaus and 6 more

Open access · bronzeAbstract read
In one paragraph

Article in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 89 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
89citing papers in PubMed, 2 pooled it
8.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

89 citing papers in PubMed, 2 syntheses or guidelines pooled it, 112 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. 177Lu-LNC1004 Radioligand Therapy in Patients with End-stage Metastatic Cancers: A Single-Center, Single-Arm, Phase II Study.Clinical cancer research : an official journal of the American Association for Cancer Research · 2025
    Trial
  4. Article
  5. Review
  6. Diagnostic value of [Scientific reports · 2026
    Observational
  7. Review
  8. Review
  9. Preclinical evaluation of novelAnnals of nuclear medicine · 2026
    Article
  10. Review
  11. Review
  12. Review
  13. Review
  14. Review
  15. Comparative Performance ofWorld journal of nuclear medicine · 2026
    Article
  16. Review
  17. Review
  18. Is FAP the key to unlocking treatment for rare soft-tissue sarcomas?American journal of nuclear medicine and molecular imaging · 2026
    Article
  19. Review
  20. Review

29 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 2 countries.

Justin FerdinandusDepartment of Nuclear Medicine, West German Cancer Center, University Hospital Essen, University of Duisburg-Essen, Essen, Germany, and Uital Essen, Essen, Germany.
Pedro Fragoso CostaDepartment of Nuclear Medicine, West German Cancer Center, University Hospital Essen, University of Duisburg-Essen, Essen, Germany, and Uital Essen, Essen, Germany.
Lukas KesslerDepartment of Nuclear Medicine, West German Cancer Center, University Hospital Essen, University of Duisburg-Essen, Essen, Germany, and Uital Essen, Essen, Germany.
Manuel WeberDepartment of Nuclear Medicine, West German Cancer Center, University Hospital Essen, University of Duisburg-Essen, Essen, Germany, and Uital Essen, Essen, Germany.
Nader HirmasDepartment of Nuclear Medicine, West German Cancer Center, University Hospital Essen, University of Duisburg-Essen, Essen, Germany, and Uital Essen, Essen, Germany.
Karina KostbadeGerman Cancer Consortium (DKTK), Partner Site University Hospital Essen, and German Cancer Research Center (DKFZ), Essen, Germany.
Sebastian BauerGerman Cancer Consortium (DKTK), Partner Site University Hospital Essen, and German Cancer Research Center (DKFZ), Essen, Germany.
Martin SchulerGerman Cancer Consortium (DKTK), Partner Site University Hospital Essen, and German Cancer Research Center (DKFZ), Essen, Germany.
Marit AhrensMedical Clinic II, University Hospital Frankfurt, Frankfurt am Main, Germany.
Hans-Ulrich SchildhausGerman Cancer Consortium (DKTK), Partner Site University Hospital Essen, and German Cancer Research Center (DKFZ), Essen, Germany.
Christoph RischplerDepartment of Nuclear Medicine, West German Cancer Center, University Hospital Essen, University of Duisburg-Essen, Essen, Germany, and Uital Essen, Essen, Germany.
Hong GrafeDepartment of Nuclear Medicine, West German Cancer Center, University Hospital Essen, University of Duisburg-Essen, Essen, Germany, and Uital Essen, Essen, Germany.
Jens T SivekeDepartment of Medical Oncology, West German Cancer Center, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Ken HerrmannDepartment of Nuclear Medicine, West German Cancer Center, University Hospital Essen, University of Duisburg-Essen, Essen, Germany, and Uital Essen, Essen, Germany.
Wolfgang P FendlerDepartment of Nuclear Medicine, West German Cancer Center, University Hospital Essen, University of Duisburg-Essen, Essen, Germany, and Uital Essen, Essen, Germany; wolfgang.fendler@uk-essen.de rainer.hamacher@uk-essen.de.
Rainer HamacherGerman Cancer Consortium (DKTK), Partner Site University Hospital Essen, and German Cancer Research Center (DKFZ), Essen, Germany; wolfgang.fendler@uk-essen.de rainer.hamacher@uk-essen.de.
German Cancer Research Center · DEEssen University Hospital · DEGoethe University Frankfurt · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fibroblast activation protein (FAP) is overexpressed in several solid tumors and therefore represents an attractive target for radiotheranostic applications. Recent investigations demonstrated rapid and high uptake of small-molecule inhibitors of FAP (

Indexed as

Pancreatic NeoplasmsQuinolinesThrombocytopeniaHumansPositron-Emission TomographyFAPI-46QuinolinesFAPIfibroblast activation proteinsolid tumorstheranostics

Identifiers

PMID34385340
PMCPMC9051597
OpenAlexW3187256913

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.