Evidence map›Paper›PMID 34385330›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

A broadly active fucosyltransferase LmjFUT1 whose mitochondrial localization and activity are essential in parasitic

Hongjie Guo, Sebastian Damerow, Luciana Penha, Stefanie Menzies, Gloria Polanco, Hicham Zegzouti, Michael A J Ferguson, Stephen M Beverley

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Mitochondria inter-organelle relationships in cancer protein aggregation.Frontiers in cell and developmental biology · 2022
    Review
  6. Aberrant Protein Glycosylation in Brain Cancers, with Emphasis on Glioblastoma.Advances in experimental medicine and biology · 2022
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Hongjie GuoDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110.
Sebastian DamerowDivision of Biological Chemistry and Drug Discovery, Wellcome Trust Biocentre, College of Life Science, University of Dundee, Dundee DD1 5EH, Scotland, United Kingdom.
Luciana PenhaDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110.
Stefanie MenziesDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110.
Gloria PolancoDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110.
Hicham ZegzoutiR&D Department, Promega Corporation, Madison, WI 53711.
Michael A J FergusonDivision of Biological Chemistry and Drug Discovery, Wellcome Trust Biocentre, College of Life Science, University of Dundee, Dundee DD1 5EH, Scotland, United Kingdom.
Stephen M BeverleyDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110; stephen.beverley@wustl.edu.ORCID 0000-0001-5319-0811
Washington University in St. Louis · USUniversity of Dundee · GBPromega (United States) · US

Funding

GLYCOSYLATION MUTANTS OF LEISHMANIAR01AI031078 · NIAID · WASHINGTON UNIVERSITY · PI BEVERLEY, STEPHEN M · 1992 to 2019
$11.4M
MOLECULAR GENETICS OF LEISHMANIA USING DNA TRANSFECTIONR01AI029646 · NIAID · WASHINGTON UNIVERSITY · PI BEVERLEY, STEPHEN M · 1990 to 2015
$9.3M
NIAID NIH HHS R01 AI029646NIAID NIH HHS R01 AI031078Wellcome TrustWellcome Trust 101842/Z/13/Z
6 · The paper itself

Abstract

Glycoconjugates play major roles in the infectious cycle of the trypanosomatid parasite

Indexed as

Amino Acid SequenceCulture MediaFucosyltransferasesGalactoside 2-alpha-L-fucosyltransferaseGene Expression Regulation, EnzymologicLeishmania majorMitochondriaMutationPlasmidsProtein TransportProtozoan ProteinsCulture MediaFucosyltransferasesGalactoside 2-alpha-L-fucosyltransferaseProtozoan Proteinschemotherapyfucoseglycobiologyglycosyltransferasetrypanosomatid protozoan parasites

Identifiers

PMID34385330
PMCPMC8379939
OpenAlexW3191762316

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.