Evidence map›Paper›PMID 34385268›Full record

ArticleThe European respiratory journal2022

Obesity, tidal volume, and pulmonary deposition of fine particulate matter in children with asthma.

Nima Afshar-Mohajer, Tianshi David Wu, Rebecca Shade, Emily Brigham, Han Woo, Megan Wood, Rachelle Koehl, Kirsten Koehler, Jason Kirkness, Nadia N Hansel and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The European respiratory journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Review
  2. Article
  3. Examining the Link between Air Quality (PM, SOJournal of clinical medicine · 2024
    Review
  4. Review
  5. An Issue of Caliber: The Airway Tree and Air Pollution Susceptibility.American journal of respiratory and critical care medicine · 2024
    Article
  6. Article
  7. Review
  8. Review
  9. Review
  10. Ambient Air Pollution Exposure and Sleep Quality in COPD.Chronic obstructive pulmonary diseases (Miami, Fla.) · 2023
    Article
  11. Obesity-related asthma in children and adolescents.The Lancet. Child & adolescent health · 2022
    Review
  12. Air pollution, metabolites and respiratory health across the life-course.European respiratory review : an official journal of the European Respiratory Society · 2022
    Review
  13. Article
  14. An Overview of the Obese-Asthma Phenotype in Children.International journal of environmental research and public health · 2022
    Review
  15. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Nima Afshar-MohajerDept of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Tianshi David WuDivision of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0000-0003-4906-3232
Rebecca ShadeKrieger School of Arts and Sciences, Johns Hopkins University, Baltimore, MD, USA.
Emily BrighamDivision of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0000-0002-8449-5420
Han WooDivision of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Megan WoodDivision of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Rachelle KoehlDivision of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Kirsten KoehlerDept of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Jason Kirkness4DMedical, Woodland Hills, CA, USA.
Nadia N HanselDivision of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Gurumurthy RamchandranDept of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Meredith C McCormackDivision of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA mmccor16@jhmi.edu.

Funding

The role of obesity in biological responses to particulate matter in miceP50ES018176 · NIEHS · JOHNS HOPKINS UNIVERSITY · PI HANSEL, NADIA N · 2015 to 2019
$4.8M
Disposable Respiratory Flow Measurement DeviceR44HL091687 · NHLBI · KEY TECHNOLOGIES, INC. · PI LANE, BENJAMIN R · 2008 to 2010
$1.3M
Insulin Resistance, Pre-Diabetes, and Diabetes in Obesity-Associated AsthmaK23HL151669 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI WU, TIANSHI DAVID · 2021 to 2025
$1.0M
Relationship Between Indoor Ultrafine Particle Exposure and Respiratory Morbidity, Inflammation, and Oxidative Stress in Children with AsthmaK23ES029105 · NIEHS · UNIVERSITY OF BRITISH COLUMBIA · PI BRIGHAM, EMILY · 2019 to 2022
$755k
NHLBI NIH HHS K23 HL151669NHLBI NIH HHS R44 HL091687NIEHS NIH HHS K23 ES029105NIEHS NIH HHS P50 ES018176
6 · The paper itself

Abstract

backgroundObese children with asthma are more vulnerable to air pollution, especially fine particulate matter (PM

objectiveTo investigate the association of BMI with breathing patterns and deposition of inhaled PM

methodsBaseline data from a prospective study of children with asthma were analysed (n=174). Tidal breathing was measured by a pitot-tube flowmeter, from which tidal volume, respiratory rate and minute ventilation were obtained. The association of BMI z-score with breathing patterns was estimated in a multivariable model adjusted for age, height, race, sex and asthma severity. A particle dosimetry model simulated PM

resultsHigher BMI was associated with higher tidal volume (adjusted mean difference (aMD) between obese and normal-range BMI of 25 mL, 95% CI 5-45 mL) and minute ventilation (aMD 453 mL·min

conclusionsObese children with asthma breathe at higher tidal volumes that may increase the efficiency of PM

Indexed as

Air PollutantsAir PollutionAsthmaPediatric ObesityChildEnvironmental ExposureHumansLungParticulate MatterProspective StudiesTidal VolumeAir PollutantsParticulate Matter

Identifiers

PMID34385268
PMCPMC8837716

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.