Evidence map›Paper›PMID 34385236›Full record

ArticleBMJ open2021

Point-of-care testing and treatment of sexually transmitted and genital infections during pregnancy in Papua New Guinea (WANTAIM trial): protocol for an economic evaluation alongside a cluster-randomised trial.

Neha Batura, Olga Pm Saweri, Andrew Vallely, William Pomat, Caroline Homer, Rebecca Guy, Stanley Luchters, Glen Mola, Lisa M Vallely, Christopher Morgan and 21 more

Open access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Selection and reporting of usual care comparators when designing primary care trials of complex health interventions: a systematic review.The British journal of general practice : the journal of the Royal College of General Practitioners · 2025
    Pooled it
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

31 authors at 11 institutions in 6 countries.

Neha BaturaInstitute for Global Health, University College London, London, UK n.batura@ucl.ac.uk.ORCID 0000-0002-8175-8125
Olga Pm SaweriThe Kirby Institute, University of New South Wales, Sydney, New South Wales, Australia.ORCID 0000-0001-5142-8355
Andrew VallelyThe Kirby Institute, University of New South Wales, Sydney, New South Wales, Australia.ORCID 0000-0003-1558-4822
William PomatThe Papua New Guinea Institute of Medical Research, Goroka, Papua New Guinea.
Caroline HomerThe Burnet Institute, Melbourne, Victoria, Australia.
Rebecca GuyThe Papua New Guinea Institute of Medical Research, Goroka, Papua New Guinea.
Stanley LuchtersThe Burnet Institute, Melbourne, Victoria, Australia.
Glen MolaSchool of Medicine and Health Sciences, University of Papua New Guinea, Port Moresby, Papua New Guinea.
Lisa M VallelyThe Kirby Institute, University of New South Wales, Sydney, New South Wales, Australia.ORCID 0000-0002-8247-7683
Christopher MorganThe Burnet Institute, Melbourne, Victoria, Australia.
Grace KariwigaMilne Bay Provincial Health Authority, Alotau, Papua New Guinea.
Handan WandThe Kirby Institute, University of New South Wales, Sydney, New South Wales, Australia.
Stephen RogersonDepartment of Medicine, The Doherty Institute, University of Melbourne, Melbourne, Victoria, Australia.
Sepehr N TabriziThe Royal Women's Hospital, Parkville, Victoria, Australia.
David M WhileyThe University of Queensland Centre for Clinical Research, Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia.
Nicola LowInstitute of Social and Preventive Medicine, University of Bern, Bern, Switzerland.ORCID 0000-0003-4817-8986
Rosanna W PeelingDepartment of Clinical Research, London School of Hygiene and Tropical Medicine, London, UK.
Peter M SibaThe Papua New Guinea Institute of Medical Research, Goroka, Papua New Guinea.
Michaela RiddellThe Kirby Institute, University of New South Wales, Sydney, New South Wales, Australia.
Moses LamanPapua New Guinea Institute of Medical Research, Madang, Papua New Guinea.
John BolngaThe Kirby Institute, University of New South Wales, Sydney, New South Wales, Australia.
Leanne J RobinsonThe Burnet Institute, Melbourne, Victoria, Australia.
Jacob MorewayaMilne Bay Provincial Health Authority, Alotau, Papua New Guinea.
Steven BadmanThe Kirby Institute, University of New South Wales, Sydney, New South Wales, Australia.
Angela Kelly-HankuThe Kirby Institute, University of New South Wales, Sydney, New South Wales, Australia.
Pamela J TolimanThe Papua New Guinea Institute of Medical Research, Goroka, Papua New Guinea.
Wilfred PeterMadang Provincial Health Authority, Madang, Papua New Guinea.
Elizabeth PeachThe Burnet Institute, Melbourne, Victoria, Australia.
Suzanne GarlandMicrobiology and Infectious Diseases Department, The Royal Women's Hospital, Parkville, Victoria, Australia.
John KaldorThe Kirby Institute, University of New South Wales, Sydney, New South Wales, Australia.
Virginia WisemanThe Kirby Institute, University of New South Wales, Sydney, New South Wales, Australia.
UNSW Sydney · AUPapua New Guinea Institute of Medical Research · PGBurnet Institute · AURoyal Women's Hospital · AULondon School of Hygiene & Tropical Medicine · GBThe University of Melbourne · AUThe University of Queensland · AUUniversity College London · GBUniversity of Bern · CHUniversity of Papua New Guinea · PGUniversity of Technology Sydney · AU

Funding

Medical Research Council MR/N006089/1Wellcome Trust
6 · The paper itself

Abstract

introductionLeft untreated, sexually transmitted and genital infections (henceforth STIs) in pregnancy can lead to serious adverse outcomes for mother and child. Papua New Guinea (PNG) has among the highest prevalence of curable STIs including syphilis, chlamydia, gonorrhoea, trichomoniasis and bacterial vaginosis, and high neonatal mortality rates. Diagnosis and treatment of these STIs in PNG rely on syndromic management. Advances in STI diagnostics through point-of-care (PoC) testing using GeneXpert technology hold promise for resource-constrained countries such as PNG. This paper describes the planned economic evaluation of a cluster-randomised cross-over trial comparing antenatal PoC testing and immediate treatment of curable STIs with standard antenatal care in two provinces in PNG. METHODS AND ANALYSIS: Cost-effectiveness of the PoC intervention compared with standard antenatal care will be assessed prospectively over the trial period (2017-2021) from societal and provider perspectives. Incremental cost-effectiveness ratios will be calculated for the primary health outcome, a composite measure of the proportion of either preterm birth and/or low birth weight; for life years saved; for disability-adjusted life years averted; and for non-health benefits (financial risk protection and improved health equity). Scenario analyses will be conducted to identify scale-up options, and budget impact analysis will be undertaken to understand short-term financial impacts of intervention adoption on the national budget. Deterministic and probabilistic sensitivity analysis will be conducted to account for uncertainty in key model inputs. ETHICS AND DISSEMINATION: This study has ethical approval from the Institutional Review Board of the PNG Institute of Medical Research; the Medical Research Advisory Committee of the PNG National Department of Health; the Human Research Ethics Committee of the University of New South Wales; and the Research Ethics Committee of the London School of Hygiene and Tropical Medicine. Findings will be disseminated through national stakeholder meetings, conferences, peer-reviewed publications and policy briefs. TRIAL REGISTRATION NUMBER: ISRCTN37134032.

Indexed as

Premature BirthSexually Transmitted DiseasesChildCost-Benefit AnalysisFemaleGenitaliaHumansInfant, NewbornPapua New GuineaPoint-of-Care TestingPregnancyRandomized Controlled Trials as Topichealth economicsprotocols & guidelinespublic health

Identifiers

PMID34385236
PMCPMC8362726
OpenAlexW3192262036

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.