Evidence map›Paper›PMID 34385153›Full record

ArticleeNeuro

Reciprocal Changes in Voltage-Gated Potassium and Subthreshold Inward Currents Help Maintain Firing Dynamics of AVPV Kisspeptin Neurons during the Estrous Cycle.

J Rudolph Starrett, R Anthony DeFazio, Suzanne M Moenter

Open access · goldAbstract read
In one paragraph

Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

J Rudolph StarrettDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109.ORCID 0000-0002-0073-0252
R Anthony DeFazioDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109.ORCID 0000-0001-7302-7528
Suzanne M MoenterDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109 smoenter@umich.edu.ORCID 0000-0001-9812-0497
University of Michigan · US

Funding

Central Actions of Estrogens: Effects on GnRH NeuronsR01HD041469 · NICHD · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI Suzanne M MOENTER · 2002 to 2026
$8.8M
Defining the neurophysiologic mechanisms engaged by estradiol feedback in regulating reproductive neuroendocrine functionF31HD097830 · NICHD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI STARRETT, JOSEPH RUDOLPH · 2018 to 2021
$142k
NICHD NIH HHS F31 HD097830NICHD NIH HHS R01 HD041469
6 · The paper itself

Abstract

Kisspeptin-expressing neurons in the anteroventral-periventricular nucleus (AVPV) are part of a neural circuit generating the gonadotropin-releasing hormone (GnRH) surge. This process is estradiol-dependent and occurs on the afternoon of proestrus in female mice. On proestrus, AVPV kisspeptin neurons express more kisspeptin and exhibit higher frequency action potentials and burst firing compared with diestrus, which is characterized by a pulsatile rather than a prolonged surge of GnRH secretion. We hypothesized changes in voltage-gated potassium conductances shape activity profiles of these cells in a cycle-dependent manner. Whole-cell voltage-clamp recordings of GFP-identified AVPV kisspeptin neurons in brain slices from diestrous and proestrous mice revealed three subcomponents of the voltage-sensitive K

Indexed as

KisspeptinsPotassiumAnimalsEstradiolEstrous CycleFemaleGonadotropin-Releasing HormoneHypothalamus, AnteriorMiceNeuronsEstradiolGonadotropin-Releasing HormoneKisspeptinsPotassiumAVPVestrous cycleexcitabilitykisspeptinpositive feedbackpotassium

Identifiers

PMID34385153
PMCPMC8422850
OpenAlexW3191115864

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.