Evidence map›Paper›PMID 34385145›Full record

ArticleDiabetes care2021

Gestational Diabetes and Incident Heart Failure: A Cohort Study.

Justin B Echouffo-Tcheugui, Jun Guan, Ravi Retnakaran, Baiju R Shah

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Diabetes care, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 4 pooled it
5.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 4 syntheses or guidelines pooled it, 44 citations in OpenAlex.

  1. Pooled it
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  6. Sexual dimorphism in the liver.Nature reviews. Gastroenterology & hepatology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 2 countries.

Justin B Echouffo-TcheuguiDivision of Endocrinology, Diabetes and Metabolism, Department of Medicine, Johns Hopkins University, Baltimore, MD jechouf1@jhmi.edu.ORCID https://orcid.org/0000-0002-8460-1617
Jun GuanInstitute for Clinical Evaluative Sciences, Toronto, Ontario, Canada.
Ravi RetnakaranLeadership Sinai Centre for Diabetes, Mount Sinai Hospital, Toronto, Ontario, Canada.ORCID https://orcid.org/0000-0003-1989-027X
Baiju R ShahInstitute for Clinical Evaluative Sciences, Toronto, Ontario, Canada.ORCID https://orcid.org/0000-0003-3598-3628
Institute for Clinical Evaluative Sciences · CAJohns Hopkins University · USMount Sinai Hospital · CASunnybrook Health Science Centre · CA

Funding

Establishing the Pathways Between Diabetes and Cardiac Dysfunction: Epidemiology, Biomarkers, and ImagingK23HL153774 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI ECHOUFFO TCHEUGUI, JUSTIN BASILE · 2020 to 2024
$991k
NHLBI NIH HHS K23 HL153774
6 · The paper itself

Abstract

objectiveTo assess whether gestational diabetes mellitus (GDM) is associated with an increased risk of heart failure (HF). RESEARCH DESIGN AND

methodsWe conducted a population-based cohort study using information from the Ministry of Health and Long-Term Care of Ontario (Canada) health care administrative databases. We identified all women in Ontario with a GDM diagnosis with a live birth singleton delivery between 1 July 2007 and 31 March 2018. Women with diabetes or HF before pregnancy were excluded. GDM was defined based on laboratory test results and diagnosis coding. The primary outcome was incident HF hospitalization over a period extending from the index pregnancy until 31 March 2019. The secondary outcome was prevalent peripartum cardiomyopathy at index pregnancy. Estimates of association were adjusted for relevant cardiometabolic risk factors.

resultsAmong 906,319 eligible women (mean age 30 years [SD 5.6], 50,193 with GDM [5.5%]), there were 763 HF events over a median follow-up period of 7 years. GDM was associated with a higher risk of incident HF (adjusted hazard ratio [aHR] 1.62 [95% CI 1.28, 2.05]) compared with no GDM. This association remained significant after accounting for chronic kidney disease, postpartum diabetes, hypertension, and coronary artery disease (aHR 1.39 [95% CI 1.09, 1.79]). GDM increased the odds of peripartum cardiomyopathy (adjusted odds ratio 1.83 [95% CI 1.45, 2.33]).

conclusionsIn a large observational study, GDM was associated with an increased risk of HF. Consequently, diabetes screening during pregnancy is suggested to identify women at risk for HF.

Identifiers

PMID34385145
PMCPMC8929190
OpenAlexW3192696067

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.