ArticleJournal of orthopaedic surgery and research2021
Epidemiology and microbiology of fracture-related infection: a multicenter study in Northeast China.
Article in Journal of orthopaedic surgery and research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed.
- A protonation/degradation dual control pH-responsive LVF delivery system with rod-shaped core-shell structure for the treatment of bone infections.Materials today. Bio · 2025Article
- Management and Treatment Strategies for Distal Tibia and Ankle Infections: Our Clinical Experience.Journal of clinical medicine · 2025Article
- Fracture-Related Infections: Current Status and Perspectives from the International Society of Antimicrobial Chemotherapy.Antibiotics (Basel, Switzerland) · 2025Review
- [Recent advances regarding diagnosis and treatment of fracture-related infection].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2025Review
- Soft tissue coverage before 12 days prevents fracture-related infection in IIIB open tibial fractures in young and healthy patients.OTA international : the open access journal of orthopaedic trauma · 2025Article
- Article
- Incidence and Risk Factors of Infection After Fracture Fixation: A Multicenter Cohort Study.Orthopaedic surgery · 2025Article
- Fracture-related infections after osteosynthesis for hip fracture are associated with higher mortality: A retrospective single-center cohort study.Acta orthopaedica · 2024Article
- Material-based treatment strategies against intraosseous implant biofilm infection.Biochemistry and biophysics reports · 2024Review
- Pathogens in FRI - Do bugs matter? - An analysis of FRI studies to assess your enemy.Journal of orthopaedics · 2024Article
- Multisite Study of the Management of Musculoskeletal Infection After Trauma: The MMUSKIT Study.Open forum infectious diseases · 2024Article
- The Microbiological Profile and Antibiotic Susceptibility of Fracture Related Infections in a Low Resource Setting Differ from High Resource Settings: A Cohort Study from Cameroon.Antibiotics (Basel, Switzerland) · 2024Article
- Delayed rib plating and lung herniation repair in a traumatic chest injury after thoracotomy: A case report.International journal of surgery case reports · 2024Article
- Infection with multi‑drug resistant organisms in patients with limb fractures: Analysis of risk factors and pathogens.Biomedical reports · 2024Article
- Fracture-Related Infection-Epidemiology, Etiology, Diagnosis, Prevention, and Treatment.Deutsches Arzteblatt international · 2024Review
- Multiplexed bacterial pathogen detection and clinical characteristics of orthopedic infection in hospitalized patients.Frontiers in cellular and infection microbiology · 2024Article
- Prevalence, resistance profiles and factors associated with skin and soft-tissue infections at Jinja regional referral hospital: A retrospective study.PLOS global public health · 2024Article
- Exploring the Microbial Landscape of Bone and Joint Infections: An Analysis Using 16S rRNA Metagenome Sequencing.Infection and drug resistance · 2024Article
- Analysis of fracture-related infections from Swedish insurance claims between 2011 and 2021.Scientific reports · 2023Article
- Microbiological Profile of Fracture Related Infection at a UK Major Trauma Centre.Antibiotics (Basel, Switzerland) · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis study aimed to explore the epidemiological and microbiological characteristics of fracture-related infection (FRI), analyze the drug resistance characteristics of major pathogens, and provide timely and relatively complete clinical and microbiological data for antimicrobial treatment of FRI.
methodsThe clinical and microbiological data of patients with FRI from January 1, 2011, to December 31, 2020, were collected from three tertiary hospitals in Northeast China. The automatic microbial analysis system was used for strain identification and drug susceptibility testing, and the drug susceptibility results were determined in accordance with the latest Clinical and Laboratory Standards Institute (CLSI) criteria (as applicable each year).
resultsA total of 744 patients with FRI were enrolled. The incidence of FRI was about 1.5%, and 81.7% were male patients, with an average age of 48.98 ± 16.01 years. Open fractures accounted for 64.8%. Motor crush (32.8%) and falling (29.8%) were the main causes of injuries. The common sites of infection were the tibia and fibula (47.6%), femur (11.8%), foot (11.8%), and hand (11.6%). A total of 566 pathogenic bacteria were cultured in 378 patients with positive bacterial cultures, of which 53.0% were Gram-positive bacteria and 47.0% were Gram-negative bacteria. The most common pathogen at all sites of infection is Staphylococcus aureus. Staphylococcus aureus had a high resistance rate to penicillin (PEN), erythromycin (ERY), and clindamycin (CLI), exceeding 50%. Methicillin-resistant Staphylococcus aureus (MRSA) was more than 80% resistant to CLI and ERY.
conclusionsThe incidence of FRI in Northeast China was at a low level among major medical centers nationwide. Staphylococcus aureus was still the main pathogen causing bone infections, and the proportion of MRSA was lower than reported abroad, but we have observed an increase in the proportion of infections. Enterobacteriaceae have a higher resistance rate to third-generation cephalosporins and quinolones. For Enterobacteriaceae, other sensitive treatment drugs should be selected clinically.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.